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Prof. Omu Anzala KAVI University of Nairobi

KENYA AIDS VACCINE INITIATIVE; A CENTRE OF EXCELLENCE FOR HIV VACCINE/PREVENTION TRIALS IN EAST AFRICA. Prof. Omu Anzala KAVI University of Nairobi. ORGANIZATIONAL STRUCTURE. OBJECTIVE #1.

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Prof. Omu Anzala KAVI University of Nairobi

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  1. KENYA AIDS VACCINE INITIATIVE; A CENTRE OF EXCELLENCE FOR HIV VACCINE/PREVENTION TRIALS IN EAST AFRICA Prof. Omu Anzala KAVI University of Nairobi

  2. ORGANIZATIONAL STRUCTURE .

  3. OBJECTIVE #1 • TO ESTABLISH KAVI AS A CENTER OF EXCELLENCE FOR THE TRAINING OF HEALTH CARE PROFESSIONALS IN THE CONDUCT OF CLINICAL TRIALS • Annual courses covering various aspects of clinical trials, targeted to research staff from the region • Building internal capacity to conduct research through training of KAVI clinical staff • Establishment of the KAVI Clinical Research Training Centre  (CRTC)

  4. Progress Report: 2010 - 2013 • Establishment of the KAVI Clinical Research Training Centre  (CRTC). • Dedicated space within KAVI to house a library of both virtual and physical resources • Eight computers/work stations set up (Beneficiaries- Departmental Staff and Masters/PhD students enrolled in the program) • Internet access • Purchase of reference books • Access to international journals • Training • Development of 3-day GCP training modules for clinical trial staff in the East African region • Building internal capacity for clinical research • Supported 3 staff to train in data management and research methodology

  5. OBJECTIVE #2 • TO ENHANCE KAVI’s LABORATORY CAPACITY TO PERFORM STATE-OF-THE ART IMMUNE MONITORING OF HIV VACCINE TRIALS • Design onsite courses in GCLP • Establish mentorship capacity in immunology for lab staff and students • Identify two students for training at PhD level in basic sciences • Establish a mucosal immunology lab

  6. Laboratory Progress Report: 2010- 2013 • 2 PhD Students in basic science are being supported by the program • Technology Transfer/Infrastructure upgrade • Mucosal immunology lab has been established • Design and delivery of courses:- • GCLP – Good Clinical and Laboratory Practice (80 trained- Kenya/Tanzania) • LQMS – Laboratory Quality Management Systems (35 trained- Kenya) • 4 staff have gone for external placements • University of Manitoba, • University of Toronto and • Human Immunology Laboratory (HIL), Imperial College, London James Onyango: PhD student supported by IDRC program

  7. OBJECTIVE #3 • TO BUILD VACCINE LITERACY AND ACCEPTANCE AMONG LOCAL COMMUNITIES AND POLICY MAKERS, • Develop courses in community issues and vaccine literacy • Identify two students for training in social science at PhD level • Advocate for vaccines among stakes holders and policy makers • Improve the knowledge about vaccines among health care workers

  8. Progress Report: 2010- 2013 • Conducted six trainings to provide vaccine information to Kenya Medical Training College (KMTC) Lecturers • Trained staff in colleges spanning from Kisumu to Mombasa • KMTC produces >60% of all the medical personnel in Kenya • Plans by KMTC management to incoporate a unit on vaccines within their training curriculum • Supporting the training of 2 PhD student in social sciences

  9. OBJECTIVE #4 • TO ENHANCE THE CAPACITY OF LOCAL ETHICS REVIEW BOARDS AND INSTITUTIONAL ADMINISTRATORS • Establish the number of ethics review boards in Kenya • Establish the process of review • Develop training materials and offer training to enhance the review process

  10. Progress Report: 2010- 2013 Collaboration with National Council for Science and Technology to identify training gaps: Five accredited Ethics Committees as of Aug 2011 Existence of several Ethics committees that were not accredited by the Council Developed a training manual for ethics review boards Conducted regional training workshops for ethics review boards and institutional administrators

  11. Work in Progress…(2013- 2014)

  12. Work in progress: Mucosal Studies- • HIV transmits primarily via mucosal route (horizontal & vertical transmission). • - An ideal vaccine should induce both systemic and mucosal humoral and cellular responses to neutralize HIV at this portal of entry • - Rapid loss of T cells occurs in mucosal tissues post-infection, most notably the gut Fresh semen

  13. Acknowledgements • GHRI • International AIDS Vaccine Initiative • Afri-Can Forum • Advisory Board Members – • Prof. Keith Fowke(University of Manitoba), • Prof. Rupert Kaul(University of Toronto), • Prof. Aboud Said (Tanzania), • Prof. Fred Nalugoda(Uganda), • Dr. Etienne Karita(Rwanda) and • Dr. Robert Kimutai(Kenya)

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