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Tuberculosis Transmission Knows No Borders: Genotype Clusters Along Texas-Mexico Border

Tuberculosis Transmission Knows No Borders: Genotype Clusters Along Texas-Mexico Border. Nicole Evert, MS Genotyping Coordinator Texas Department of State Health Services. Collaborators: Ken Jost Jr , Maria Rodriguez, Cindy Tafolla , Ann Tyree and Charles Wallace .

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Tuberculosis Transmission Knows No Borders: Genotype Clusters Along Texas-Mexico Border

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  1. Tuberculosis Transmission Knows No Borders: Genotype Clusters Along Texas-Mexico Border Nicole Evert, MS Genotyping Coordinator Texas Department of State Health Services Collaborators: Ken JostJr, Maria Rodriguez, Cindy Tafolla, Ann Tyree and Charles Wallace No funding sources or relationships to disclose and no conflict of interest to disclose

  2. Background • Three binational programs created to address the high incidence of TB along Texas-Mexico border by serving TB cases in sister-city communities • Services provided include: • directly observed therapy • contact investigations • laboratory services, including genotyping • TB education • referrals • Each year an estimated 500 – 750 TB cases require TB case management on both sides of the U.S.-Mexico border (unpublished data)

  3. Genotype Clusters in Texas 7,119 Tuberculosis (TB) cases were genotyped in Texas from 2005-2010 1,823 (26%) binational TB cases 1,403 (77%) were clustered 5,296 (74%) Texas (TX) TB cases 2,777 (52%) were clustered Clusters with both Texas and Binational cases were 3 times larger than clusters with only Texas or only Binational cases

  4. Genotype: PCR02252 (Spoligotype: 777777607760731,24-locus MIRU-VNTR: 2242226153321-543324115224)

  5. Genotype: PCR02252 (Spoligotype: 777777607760731, 24-locus MIRU-VNTR: 2242226153321-543324115224) 2008 INH RIF EMB INH RIF SM INH RIF EMB INH RIF EMB INH INH C F E A D B Street B L M H J N I G K INH RIF PZA INH RIF INHRIF INH RIF 2009 INH INH INH INH Jail Street A INH EMB INHRIF INH RIF INH INH 2010 R Q O P S INH RIF EMB INH EMB INH 2011 Texas Tamaulipas, MX Known Link Possible Link Report Year V T U

  6. Conclusion & Next Steps Preliminary cluster analysis of PCR02252 suggests that there may be ongoing transmission among Texas and Binational cases across border communities, but more information is needed Improving management for patients and interrupting of TB transmission along the border depends on: Consistent formats for data collection Sharing data Patient information Contact investigations Centralized Data Analysis Joint planning and interventions

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