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Shine-Dalgarno

Shine-Dalgarno

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Shine-Dalgarno

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  1. John Shine and Lynn Dalgarno are two Australian scientists who contacted Steitz with regards to their work on what is now called the Shine-Dalgarno sequence. • In addition to Steitz’s citation of their PNAS (1974), one might also want to read their paper in Nature (1975) • The Shine-Dalgarno region (seen highlighted in Fig. 1 of the annotated paper) is a ribosomal binding site located upstream of the start codon AUG. It helps recruit the ribosome to the mRNA to initiate protein synthesis by aligning it properly with the start codon.