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The Synapse: A Brief History and Mechanisms of Communication

Explore the fascinating history and mechanisms of synaptic communication, including neurotransmitters, synaptic plasticity, and long-term potentiation.

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The Synapse: A Brief History and Mechanisms of Communication

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  1. A BRIEF HISTORY OF THE SYNAPSE A BRIEF HISTORY OF THE SYNAPSE DAVID SANTUCCIQUANTITATIVE BIOLOGY BOOTCAMP 2009 DAVID SANTUCCIQUANTITATIVE BIOLOGY BOOTCAMP 2009

  2. Santiago Ramón y Cajal Drawing of Chick Cerebellum

  3. + + + + + + + + + + - - - - - - - - - - Extracellular Space Na+ Cl- K+ Ca2+ -70 mV K+ Na+ Cl- Ca2+ Intracellular Space

  4. + + + + + + + + + + + + + + + + - - - - - - - - - - - - - - - - -70 mV -70 mV

  5. + + + + + + + + + + + + + + + + - - - - - - - - - - - - - - - - -70 mV -70 mV

  6. Neurotransmitters Excitatory Modulatory Acetylcholine Glutamate Dopamine Inhibitory Norepinephrine GABA Serotonin

  7. Bernard Katz Frog Neuromuscular Junction (NMJ)

  8. Bernard Katz End Plate Potentials Miniature EPPs

  9. Bernard Katz

  10. Dendritic Spines Excitatory Synapse Inhibitory Synapse

  11. "Let us assume then that the persistence or repetition of a reverberatory activity (or "trace") tends to induce lasting cellular changes that add to its stability. …When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased." Donald Hebb

  12. Terje Lømo

  13. Long Term Potentiation

  14. Long Term Potentiation Depolarization of Postsynaptic Cell Release of NMDA Receptor Mg2+ Block Ca2+ Influx Ca2+-dependent Signaling Cascades Insertion of AMPA Receptors Protein Synthesis

  15. To Be Continued… To Be Continued…

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