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RITONAVIR INTERACTIONS AND SIDE EFFECTS

RITONAVIR INTERACTIONS AND SIDE EFFECTS. Present by PEERAKARN BANJERDKIJ. OUTLINE. Introduction HIV Therapy Types of HIV-drugs Protease Inhibitors work Ritonavir Pharmacology Drug Interactions Side effects Conclusion. INTRODUCTION.

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RITONAVIR INTERACTIONS AND SIDE EFFECTS

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  1. RITONAVIR INTERACTIONS AND SIDE EFFECTS Present by PEERAKARN BANJERDKIJ

  2. OUTLINE • Introduction • HIV Therapy • Types of HIV-drugs • Protease Inhibitors work • Ritonavir • Pharmacology • Drug Interactions • Side effects • Conclusion

  3. INTRODUCTION Why is the “HIV Therapy” called “multiple therapies”? Ans. : Immune system What is the “medical problem”? Ans. : Drug interactions How many types of HIV-drugs? Ans. : 3 Types

  4. Types of HIV-drugs • 2 main groups • 1. Reverse Transcriptase • 1.1 Nucleoside Reverse Transcriptase • Inhibitors (NRTIs) • zidovudine (AZT) • didanosine (ddI) • 1.2 Non-nucleoside Reverse Transcriptase • Inhibitors (NNRTIs) • nevirapine • delaviridine • 2. Protease Inhibitors (PIs) • indinavir • ritonavir

  5. What is HIV protease?

  6. How do protease inhibitors work?

  7. How do protease inhibitors differ from other available anti-HIV drugs?

  8. OUTLINE • Introduction • Ritonavir • Pharmacology • Drug Interactions • Side effects

  9. RITONAVIR Pharmacology • Block maturation of virus • By interfering • Act at the stage of HIV replication cycle • Produce resistance • Bound plasma 98-99% • Cross resistance • combine with NNRTIs or NRTIs • combine with PIs Cross resistance

  10. OUTLINE • Introduction • Ritonavir • Pharmacology • Drug Interactions • Side effects

  11. RITONAVIR Combinations & Interactions What types of other medications can interact with PIs? Ans.1 : HIV-HIV drugs - Combination Therapy - Double-Drug ; PIs + PIs , PIs + NRTIs - Triple-Drug ; PIs+PIs+NNRTIs Ans.2 : HIV-Other drugs ; PIs+Antivirals

  12. RITONAVIR Drug Interactions • Metabolized by P450 at the liver • Combine with competition drugs ; can occur 1. Metabolism of these drugs 2. Concentration of Ritonavir and these drugs

  13. DRUG INTERACTION Between Other drugs and Ritonavir http://www.hivinsite.UCSF.edu/topics/research_advances/2098.339b.html

  14. DRUG INTERACTION Between Other drugs and PIs http://www.thebody.com/hivatis/agents1/table14.html

  15. DRUG COMBINATION Between PIs and PIs * Invirase or Fortovase , + Conducted with Invirase , # with Fortovase http://www.thebody.com/hivatis/agents1/table15.html

  16. OUTLINE • Introduction • Ritonavir • Pharmacology • Drug Interactions • Side effects

  17. SIDE EFFECTS Adverse Drug Reaction http://www.utoledo.edu/pharmacy/clinical/aids.html http://www.iapac.org/clinmgt/avtherapies/patient/proinbk.html#top

  18. HIV Drugs -Toxicities SIDE EFFECTS http://www.thebody.com/hivatis/agents1/table16.html

  19. OUTLINE • Introduction • Ritonavir • Pharmacology • Drug Interactions • Side effects • Conclusion

  20. CONCLUSIONS Protease Inhibitors can cure or not! Combination ; more efficiency Side effects ; different ways Resistance Problems Cross resistance problems

  21. THE END THANK YOU • Dr. SUVIT • Dr. MARIA • Mr. SOMJERD • CRI OFFIER & OUR CLASS ……...

  22. SIDE EFFECTS Advantages & Disadvantages ofClass-Sparing Regimens http://www.thebody.com/hivatis/agents1/table7.html

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