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Treatment as Prevention: The Key to an AIDS-Free Generation

Treatment as Prevention: The Key to an AIDS-Free Generation. Julio Montaner, MD Professor of Medicine, and Head, Div. of AIDS, University of British Columbia Director, BC-Centre for Excellence in HIV/AIDS at Providence Health Care Past President, International AIDS Society (2008-2010).

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Treatment as Prevention: The Key to an AIDS-Free Generation

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  1. Treatment as Prevention:The Key to an AIDS-Free Generation Julio Montaner, MDProfessor of Medicine, and Head, Div. of AIDS, University of British Columbia Director, BC-Centre for Excellence in HIV/AIDS at Providence Health Care Past President, International AIDS Society (2008-2010) AU EDITED FINAL: 03-18-13

  2. Increasing HAART Coverage within Evolving Guidelines in BC N = 7492 by the end of 2011 January 2004 Summer of 2000 Summer of 1996 Phase I Phase II Phase III Year Montaner et al, Lancet, 2010

  3. Pre-HAART CD4 counts in BC by year, 2003-2012 Lima et al, in preparation, 2013

  4. Adherence to HAART in BC by year, 1996-2012 Lima et al, in preparation, 2013

  5. HIV Drug Resistance in BC by year, 1996-2012 Lima et al, in preparation, 2013

  6. BC: All Cause Mortality (#) > 90% Decrease in All Cause Mortality among HIV Infected Individuals in BC since 1996 Montaner et al, TasP Workshop, April 2012

  7. AIDS New Cases for BC by year, 1996-2011 Lima et al, in preparation, 2013

  8. BC: HIV Prevalence and TB Incidence James Johnston, WIP, May 2013

  9. HAART Use & New HIV Diagnoses for BC by year, 1996-2012 Active on HAART HIV Incidence New HIV Diagnoses (All) New HIV Diagnoses (Ever IDU) Lima et al, in preparation, 2013

  10. Annual rates (per 100,000 population) for new cases of genital chlamydia, genital gonorrhea, infectious syphilis and hepatitis C, 1996-2012 Hepatitis C Syphilis Chlamydia Gonorrhea Lima et al, in preparation, 2013

  11. Programmatic Compliance Score • Assesses the impact of non-compliance with HIV treatment guidelines on all-cause mortality • PCS components include: • Baseline CD4 > 200/mm3 • Three CD4 in 1st year • Three VL in 1st year • Baseline resistance • Recommended HAART • Undetectable pVL at 9 months • Failure to meet a given component add one to the score • PCS predicts mortality Lima et al. PLoSONE 7(11): e47859. 2012

  12. PCS in BC 2000 to 2011 Lima et al, in preparation, 2013

  13. R Lester, M Morshed, and M Gilbert, BCMJ, May 4th 2013

  14. red = drug resistance at baseline node size = date of baseline sample

  15. HIV Diagnoses by Region and Year Public Health Agency of Canada

  16. 4th Intl HIV TREATMANT AS PREVENTION Workshop April 1st to 4th 2014 - Vancouver, BC, Canada. Link

  17. In Collaboration with PHC, VCHA, NHA, PHSA, Community, and MoH

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