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Memantine in Vascular Dementia: Subgroup Analyses

Memantine in Vascular Dementia Möbius H.J. and Stöffler A. International Psychogeriatrics 2003, 15 Suppl 1: 207-213. Memantine in Vascular Dementia: Subgroup Analyses. Analyses based on studies in patients with mild to moderate vascular dementia: Orgogozo et al. (2002) (MMM300)

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Memantine in Vascular Dementia: Subgroup Analyses

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  1. Memantine in Vascular DementiaMöbius H.J. and Stöffler A.International Psychogeriatrics 2003, 15 Suppl 1: 207-213

  2. Memantine in Vascular Dementia: Subgroup Analyses Analyses based on studies in patients with mild to moderate vascular dementia: • Orgogozo et al. (2002) (MMM300) • Wilcock et al. (2002) (MMM500) • ADAS-cog analysis by severity at baseline: • MMSE 20-22 • MMSE 15-19 • MMSE 10-14 • ADAS-cog analysis by neuroradiological findings at baseline: • Macrolesions, “Large Vessel Disease” • No macrolesions, “Small Vessel Disease” Möbius and Stöffler, Int Psychogeriatr 2003

  3. ADAS-cog mean change from baseline ITT, LOCF, N = 214 -2 -1 0 1 2 3 Pooled data Improvement ADAS-cog score difference  Memantine (20 mg/day)  Placebo Worsening 0 12 28 Week Patients with “Large Vessel Disease” Hardly Show Cognitive Decline Möbius and Stöffler, Int Psychogeriatr 2003

  4. ADAS-cog mean change from baseline ITT, LOCF, N = 553 -2 -1 0 1 2 3 Pooled data * Improvement  Memantine (20 mg/day)  Placebo Worsening 0 12 28 Week *p = 0.002 versus placebo Significant Benefit of Memantine in Patients with “Small Vessel Disease” ADAS-cog score difference Möbius and Stöffler, Int Psychogeriatr 2003

  5. Largest Benefit of Memantine in More Severely Demented Patients Mean ADAS-cog change from baseline ITT, LOCF -2 -1 0 1 2 3 4 5 -1.38 -0.80 Improvement 0.32 0.50 0.53 0.99 0.94 0.95 ADAS-cog score difference 1.35  Memantine (20 mg/day)  Placebo 2.43 Worsening 4.12 4.40 20-22 15-19 10-14 20-22 15-19 10-14 MMSE at baseline MMM500 MMM300 Möbius and Stöffler, Int Psychogeriatr 2003

  6. Summary The strongest effect of memantine on cognition was shown • in the moderately demented patient population (MMSE < 15 at baseline) and • in the subgroup of patients with “small vessel disease” (no macrolesions in CT/MRI) Möbius and Stöffler, Int Psychogeriatr 2003

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