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Characterization of pDRD4 Variants and Their Genetic Region Duplication

This study focuses on the pDRD4 gene, examining its various promoters (pDRD4-A to pDRD4-F) and their associated genetic markers. Specific variants including .-616.C/G, .-615.G/A, -.521.C/T, and a duplication at 120 bp are analyzed alongside their respective genomic locations. The investigation aims to unravel the regulatory elements from -1571 to -127 with implications for gene expression and potential phenotypic effects. The results deepen our understanding of dopamine-related pathways and their influence on behavior and neurological conditions.

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Characterization of pDRD4 Variants and Their Genetic Region Duplication

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  1. -616 C/G, -615 G/A -521 C/T 120 bp dup -501 (-1479 to -1240) + 1 3’ 5’ ATG -1571 -389 -127 -799 -668 pDRD4-A (-1571to-389) A pDRD4-B (-799 to-389) B pDRD4-C (-668 to -389) C pDRD4-D (-1571to-127) D pDRD4-E (-799 to -127) E pDRD4-F (-668 to -127) F

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