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Understanding Corona Viruses: Structure, Multiplication, and Control

This presentation covers the structure, classification, multiplication process, clinical manifestations, epidemiology, diagnosis, and control measures related to corona viruses. Topics include the structure of corona viruses, classification based on serotypes, multiplication process in nasal epithelium, clinical manifestations including rare cases of diarrhea in children, and detailed information on their pathogenesis and epidemiology. Diagnosis methods, treatment strategies focusing on symptom management and hygiene improvement, along with the absence of specific vaccines and antivirals are also discussed.

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Understanding Corona Viruses: Structure, Multiplication, and Control

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  1. Corona Viruses fackrel@Uwindsor.ca Corona.ppt

  2. Corona Viruses • Structure • Classification • Multiplication • Clinical manifestations • Epidemiology • Diagnosis • Control Baron’s Web Site

  3. Structure • Spherical or pleomorphic 80-100 nm • Enveloped • club shaped glycoprotein spikes • ss RNA sense strand

  4. Classification • Crown of envelope glycoproteins • 2 serotypes • OC43 like • 229E like

  5. Multiplication • Virus enters nasal epithelium • Uncoats • ssRNA transcribed >>> translated • mRNA nested set • common 3’ ends • only unique portion of 5’ translated

  6. Common Cold mild, acute upper respiratory tract infections Clinical Manifestations Diarrhea in children RARE!

  7. DISEASE Interferon Virus antibody Time (days) Corona Virus Pathogenesis coryza Nasal Secretions Nasopharynx

  8. Epidemiology • local epidemics • Peak incidence in Winter • last few weeks- months

  9. Diagnosis • Clinically • undistinguished from other colds • Laboratory • increase in antibody titre over time • virus difficult to isolate

  10. Control • Treat symptoms • Improve hygiene • No vaccines • No specific antivirals

  11. DONE!!!

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