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Understanding GAP and RGS GDI Roles in GTPase Activation and Inactivation

This article explores the essential functions of GTPase-activating proteins (GAPs) and regulators of G protein signaling (RGS) in managing GTPase activity. We delve into how these proteins facilitate the conversion of GTP to GDP, thereby influencing GTPase activation and inactivation. Emphasizing the significance of guanine nucleotide exchange factors (GEFs), we illustrate the balance between active (GTP-bound) and inactive (GDP-bound) states of GTPases and their implications in cellular signaling pathways.

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Understanding GAP and RGS GDI Roles in GTPase Activation and Inactivation

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  1. GAP + RGS GDI + - GTPase GTPase GDP + GTP GDP GTP GEFs Active Inactive

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