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This study explores the intricate relationships between various promoter regions, including core and distal elements, and their impact on gene regulation. By analyzing different regions such as 5' proximal, 3' distal, and within-gene configurations, we aim to elucidate the roles these sequences play in transcriptional activity. The research utilizes genomic data spanning multiple kilobases to identify regulatory hotspots and their contributions to gene expression, providing insights into the genetic architecture and functional elements influencing transcriptional dynamics.
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3’TSS -100kb -10kb 10kb 100 kb 5’TSS 5’ Distal 5’ Proximal 3’ Distal WithinGene Core 3’ Proximal A Promoter Region 1kb 2kb -2kb -1kb 10kb 2kb 3’ Core WithinGene Proximal WithinGene Distal 5’ Core Intragenic Region B