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Unraveling BDNF and Neuronal Growth Implications

Explore the multifaceted roles of Brain-derived Neurotrophic Factor (BDNF) in neuronal development, linking to antidepressant treatment and intracellular signaling pathways. Discover the diverse isoforms arising from alternative splicing and how they respond to various cues.

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Unraveling BDNF and Neuronal Growth Implications

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  1. BDNF • Brain-derived neurotrophic factor (BDNF) is a 25-kDa CNS protein implicated in neuronal cell growth and differentiation

  2. 5-HT and BDNF-regulated intracellular signal tranduction pathways

  3. A model for antidepressant treatment

  4. BDNF gene in mice has 6 upstream exons and 1 coding sequence 9 different BDNF isoforms produced by alternative splicing • Splice variants thought to contain different promoter sequences which respond to temporal, spatial and biochemical cues

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