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Filgrastim

The Reliable Life Defense. Filgrastim. Filgrastim Composition. Each vial contains: Recombinant human granulocyte colony-stimulating factor (G-CSF) 300 µg in a volume of 1 ml. Pharmacological Action.

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Filgrastim

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  1. The Reliable Life Defense Filgrastim

  2. FilgrastimComposition • Each vial contains: • Recombinant human granulocyte colony-stimulating factor (G-CSF) 300 µg in a volume of 1 ml.

  3. Pharmacological Action • Filgrastim is a glycoprotein which acts on hematopoietic cells in bone marrow, stimulating their proliferation & differentiation to neutrophils. • Filgrastimaccelerates improvement of neutrophils count & their functional activation (enhanced phagocytic ability)

  4. Filgrastim Indications • To reduce the incidence, severity & duration of neutropenia associated with chemotherapy (Interferon) • Cancer patients receiving myelosuppressive chemotherapy • Patients with acute myeloid leukemia receiving induction Chemotherapy • Patients with severe chronic neutropenia

  5. Filgrastim Indications • Cancer patients undergoing peripheral Blood Progenitor Cell Collection and Therapy • Cancer patients receiving bone marrow transplant • Patients with acute myeloid leukemia receiving induction Chemotherapy • Patients with severe chronic neutropenia

  6. Clinical Pharmacological Response Filgrastim dose: 4 to 8 mcg/kg for up to 14 consecutive days following each cycle of chemotherapy Cancer Patients Receiving Myelo-suppressive Chemotherapy Duhrsen U‚ Villeval JL‚ Boyd J‚ et al. Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 1988;72:2074-2081.

  7. Dosage & Administration • Dosage & Administration is individualized according to patient’s clinical course & average neutrophil count • Filgrastim should be given once daily by I.V. or S.C. injection (after 24 – 48 hours of administration of chemotherapy or radiotherapy)

  8. Filgrastim Dosage • Cancer patients receiving myelosuppressive chemotherapy: • 5 µg/kg body weight /day as a single daily dose by S.C. injection or I.V. infusion over 15 – 30 minutes

  9. Filgrastim Dosage • Patients with severe chronic neutropenia: • Initial dose • Congenital: 6µg/kg body weight twice daily by S.C. injection • Idiopathic: 5µg/kg body weight /day as a single S.C. injection

  10. Filgrastim Dosage • Cancer patients receiving bone marrow transplant: • 10 µg/kg body weight /day as I.V. infusion for 4 – 24 hours

  11. Filgrastim Dosage • Cancer patients undergoing peripheral Blood Progenitor Cell Collection and Therapy: • 10 µg/kg body weight /day either as a bolus or a continuous infusion at least 4 days before the first procedure for 6 – 7 days, on day 5,6,7 . • Dosemodification in case of reaching WBCs count exceeding 100,000 / mm3

  12. Filgrastim Storage • Filgrastim is kept in refrigerator at 2 – 8oC • Filgrastim can be kept at room temp. for a maximum of 24 hours • Filgrastimvial should not be shacked • Filgrastim vial should not be reused, the unused portion must be discarded

  13. Filgrastim Pack & Price • 1 vial (1 ml) … 350 L E.

  14. The Reliable Life Defense Filgrastim

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