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Understanding Chromosomes and Their Role in Cancer Development

This chapter explores the critical link between chromosomes and human genetics, focusing on how certain genes on chromosomes regulate cell growth and division. Disruptions to chromosome structure, especially near key loci, can lead to uncontrolled cell division and cancer. The Philadelphia chromosome is highlighted as the first abnormal chromosome linked to cancer, notably chronic leukemia, characterized by an overproduction of white blood cells. Additionally, the concept of reciprocal translocation is discussed, demonstrating the intricate relationship between genetics and cancer.

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Understanding Chromosomes and Their Role in Cancer Development

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    1. Chromosomes and Human Genetics Chapter 15

    2. Chromosomes & Cancer Some genes on chromosomes control cell growth and division If something affects chromosome structure at or near these loci, cell division may spiral out of control This can lead to cancer

    3. Philadelphia Chromosome First abnormal chromosome to be associated with a cancer Associated with a chronic leukemia Overproduction of white blood cells

    4. A Reciprocal Translocation

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