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Affective Disorders

Affective Disorders. Emotional States and The Limbic System. …recommended (summer) reading: Evil Genes by Barbara Oakley. The Amygdala. Classes of Affective Disorders and Diverse Brain Dysfunction. Anxiety p hobias, post-traumatic stress disorder, obsessive compulsive disorder

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Affective Disorders

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  1. Affective Disorders

  2. Emotional States and The Limbic System …recommended (summer) reading: Evil Genes by Barbara Oakley

  3. The Amygdala

  4. Classes of Affective Disorders and Diverse Brain Dysfunction • Anxiety • phobias, post-traumatic stress disorder, obsessive compulsive disorder • Neuropathology: limbic system • Psychosis • schizophrenia, multiple personality disorder • Neurobiology:dopaminergic system • Depression • post-partum, manic-depressive • Neurobiology: serotoninergic and noadrenergic systems

  5. Anxiety • hyper-alert, resistant to change, context-dependent Hippocampus Amygdala HPA Cortisol

  6. Depression • hypo-alert, ahedonia

  7. Manic-Depressive (Bipolar) • waxes and wanes across months/years, stress is normally a trigger Robert Schumann’s productivity

  8. Really? A chemical salt to treat bipolar disorder? • Lithium • can replace Na++ as a generator of action potentials • centrally decreases norephinephrine release and enhances serotonin synthesis • efficacious in humans and in mice (see work of CA McClung [PubMed])

  9. Schizophrenia • severely out-of-touch with reality, delusions of grandeur, auditory and visual hallucinations, and highly hereditable

  10. Neurobiology of Schizophrenia Hyperactivity in several brain areas Enlarged lateral ventricles Increased Dopaminergic Tonus (Euphoria)

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