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ปฏิบัติการ วิชา พยาธิวิทยา ครั้งที่ 1

ปฏิบัติการ วิชา พยาธิวิทยา ครั้งที่ 1. ภาควิชาพยาธิวิทยาและนิติเวชศาสตร์ คณะแพทยศาสตร์ มหาวิทยาลัยนเรศวร. เนื้อหา. Cell adaptation, injury and death Inflammation and Repair Hemodynamic disorder. Cell adaptation, injury and death. Cell adaptation, injury and death.

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ปฏิบัติการ วิชา พยาธิวิทยา ครั้งที่ 1

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  1. ปฏิบัติการ วิชา พยาธิวิทยา ครั้งที่ 1 ภาควิชาพยาธิวิทยาและนิติเวชศาสตร์ คณะแพทยศาสตร์ มหาวิทยาลัยนเรศวร

  2. เนื้อหา • Cell adaptation, injury and death • Inflammation and Repair • Hemodynamic disorder

  3. Cell adaptation, injury and death

  4. Cell adaptation, injury and death Reversible cell injury; • Cloudy swelling of Hepatocytes (Micros) • Fatty change of Liver (Gross&Micros) • Hyaline change; Mallory bodies in hepatocytes (Micros)

  5. Cloudy swelling of Hepatocytes (Micros)

  6. Fatty change of Liver (Gross&Micros)

  7. Fatty change of Liver (Gross&Micros)

  8. Hyaline change; Mallory bodies in hepatocytes (Micros)

  9. Cell adaptation, injury and death Irreversible injury; • Coagulative necrosis of Kidney (Renal infarct) • Coagulative necrosis of Spleen (Splenic infarct) • Liquefactive necrosis of Lung (Lung abscess) • Liquefactive necrosis of Brain (Brain infarct) • Caseous necrosis of Lymph nodes • Enzymatic fat necrosis in Acute pancreatitis

  10. Coagulative necrosis of Kidney (Gross&Micros)

  11. Coagulative necrosis of Kidney (Gross)

  12. Coagulative necrosis; Renal infarct

  13. Coagulative necrosis; Splenic infarct

  14. Liquefactive necrosis; Lung abscess

  15. Liquefactive necrosis; Brain infarct

  16. Liquefactive necrosis; Brain infarct

  17. Caseous necrosis of Lymph nodes (Gross & Micro)

  18. Caseous necrosis; TB lymph nodes

  19. Enzymatic fat necrosis in Acute pancreatitis (Gross&Micros)

  20. Cell adaptation, injury and death Cellular adaptation; • Hypertrophy ( Heart and Uterus) • Testicular atrophy • Prostatic hyperplasia Cellular accumulation; • Cholesterolosis of Gall bladder

  21. Testicular atrophy (Gross)

  22. Ventricular Hypertrophy (Gross&Micros)

  23. Hypertrophy; Pregnant uterus

  24. Prostatic hyperplasia (Gross&Micros)

  25. Cholesterolosis of Gall bladder (Gross&Micros)

  26. Inflammation and Repair Inflammatory cells; • Neutrophils • Macrophages • Lymphocytes • Plasma cells

  27. Neutrophils

  28. Macrophages

  29. Lymphocytes

  30. Plasma cells

  31. Inflammation and Repair Acute inflammation; • Acute appendicitis (Gross ) • Acute cholecystitis (Gross ) • Breast abscess (Gross )

  32. Acute appendicitis (Gross )

  33. Acute cholecystitis (Gross )

  34. Breast abscess (Gross )

  35. Inflammation and Repair Chronic cholecystitis ( Micros) Granulation tissue ( Micros) Granulomatous inflammation ( Micros) Keloid (Gross&Micros) Scar contracture (Gross )

  36. Chronic cholecystitis ( Micros)

  37. Granulation tissue ( Micros)

  38. Granulomatous inflammation ( Micros)

  39. Keloid (Gross&Micros)

  40. Hemodynamic disorders

  41. Pitting edema

  42. Pulmonary edema

  43. Pulmonary edema

  44. Hemorrhage • Petechiae  1-2 mm • Purpura  > 3 mm • Ecchymoses  1-2 cm • Hematoma

  45. Petechial hemorrhage

  46. Hematoma in Cerebral cortex

  47. Shock • Acute respiratory distress syndrome (Shock lung) - ARDS • Centrilobular hemorrhagic necrosis of liver (Shock liver)

  48. ARDS – Shock lung

  49. ARDS – Shock lung Hyaline membrane

  50. Shock liver– Nutmeg liver

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