DementiaBank Progress and Future Plans

1. DementiaBankProgress and Future Plans Michelle S. Bourgeois, PhD, CCC-SLP University of South Florida msbourgeois@usf.edu

2. Project Description: Pitt Corpushttps://dementia.talkbank.org/ • The transcripts and audio files were gathered as part of a larger protocol administered by the Alzheimer and Related Dementias Study at the University of Pittsburgh School of Medicine. • The original acquisition of the DementiaBank data was supported by NIH grants AG005133 and AG003705 to the University of Pittsburgh, and NIH-NIDCD grant R01-DC008524 for 2007-2017 to Carnegie Mellon University. • Participants included elderly controls, people with probable and possible Alzheimer’s Disease, and people with other dementia diagnoses. • Data were gathered longitudinally, on a yearly basis. • Demographic data and test results from the rest of the protocol that was administered to all participants are included on the Data Spreadsheet for the Pitt Corpus available from the DementiaBank homepage.

3. Becker, J. T., Boller, F., Lopez, O. L., Saxton, J., & McGonigle, K. L. (1994). The natural history of Alzheimer's disease: description of study cohort and accuracy of diagnosis. Archives of Neurology, 51(6), 585-594.

4. Tasks in the Alzheimer and Related Dementias Study protocol • Cookie Theft Picture Description • How many… days in a year? inches in a foot? eggs in a dozen? senators to a state? ounces in a pound?  • Yes/No Questions (from Western Aphasia Battery) Is your name Smith (Brown, Matthews)? Do you live in Toronto (Pittsburgh, Windsor)? Are you a woman (man)? Are the lights on? Is the door closed? Do you eat a banana before you peel it?  • Read given sentences • Repeat sentences after investigator He is fishing with George. Why don’t you give them some candy?  • Word fluency Name any thing you can find in a supermarket. (Timed) Name all the items I (investigator) am wearing. Things that begin with the letter “F” • Name the item that… you use to drink coffee/tea. you use to fix your hair. you use to tell the time. • What do you do with… a razor? soap? a pencil?  • Name the word that is being described A prickly plant in the desert An item used to hit a tennis ball etc.

5. How are the following words alike? Apple/banana (& Are these words names of fruits or animals?) Coat/suit (& Are these words names of clothing or fruit?)  Name the word that does not belong Dog, cat, car Fish, car, train Boy, door, man Does this sentence make sense? (If not, tell me why or correct the sentence.) He drank some coffee. Where's in the package? I’m not as tall am I am. Tell me a short, simple sentence using the given word(s) Pencil Child/hospital  Recall a story – Immediate and Delayed and Probe Questions Sometimes the story is about a July 4th event with Uncle Bill and John fishing; sometimes it’s about Thanksgiving with George, Melanie, and a trip to the city. Name the item (picture) Maze Toboggan 

6. Media and Transcript Database • Audio files were managed via Adobe Soundbooth software; • From 2008-2018 ~100 volunteer undergraduate students from the Ohio State University and University of South Florida clipped audio segments from each file and transcribed them using the CLAN program and CHAT coding conventions. • Students’ transcriptions were checked for reliability within the lab (minimun 85% agreement); then linked to the audio file. • Transcripts were uploaded to Davida Fromm, TalkBank, who re-checked reliability and made corrections to the coding. • Transcripts and linked audio files were uploaded to DementiaBank.

7. Protocol Tasks transcribed • A. Cookie These are responses to the Cookie Theft stimulus photo for the Control group and the Dementia group. • B. Fluency These are responses to the Word Fluency task for the Dementia group only. These audio files have been transcribed by undergraduate student volunteers. The CHAT transcripts are in the process of being reviewed by an experienced transcriber (July 2016). • C. Recall These are responses to the Story Recall task for the Dementia group only. These audio files have been transcribed by undergraduate student volunteers. The CHAT transcripts have not been reviewed by an experienced transcriber and should be considered rough first drafts. • D. Sentence These are responses to the Sentence Construction task for the Dementia group only.

9. All of the current samples on DementiaBank.

10. Use of the DementiaBank data • 161 DementiaBank Members from 30 countries • Publications and Presentations • 84 total to date • Publications and Conference Proceedings: 74 • Dissertation: 1 • Master’s theses: 2 • Undergraduate theses: 3 • Posters: 4

11. Conference posters using DementiaBank data

12. Future Directions • Limitation of current data set • Outdated Diagnostic parameters • Only Ad-probable, AD-possible, MCI. • Collection of new data • Define new dementia patient populations • Primary Progressive Aphasia (PPA; 3 subtypes), Frontotemporal (FTD), Lewy Body dementia, Parkinson’s dementia, Huntington’s dementia, LATE (TDP-43 protein) • Development of new Protocol • Consensus conference to develop common protocol • Develop Training/reliability procedures • Download new data for analysis