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Antianginal Agents

Antianginal Agents

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Antianginal Agents

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  1. Antianginal Agents

  2. Coronary Ischemia:Supply and Demand Economics

  3. Coronary Ischemia: Supply and Demand Economics

  4. The Grip of Angina

  5. Supply-Demand Mismatch

  6. Myocardial Oxygen Demand HeartRate Wall Stress Contractility Adapted from Runge et al, Netter’s Cardiology

  7. Determinants of Myocardial Oxygen Supply

  8. Determinants of Myocardial Oxygen Supply

  9. Coronary Flow Reserve Adapted from Maseri A, Ischemic Heart Disease, Churchill Livingstone, 1995

  10. Angina Pectoris (Chest Pain) • When the supply of oxygen and nutrients in the blood is insufficient to meet the demands of the heart, the heart muscle aches. • The heart demands a large supply of oxygen to meet the demands placed on it.

  11. Types of Angina • Chronic stable angina (also called classic or effort angina) • Unstable angina(also called preinfarction or crescendo angina) • Vasospastic angina(also called Prinzmetal’s or variant angina)

  12. Angina Drug Therapy

  13. Antianginal Agents • Nitrates • Beta blockers • Calcium channel blockers

  14. Antianginal Agents: Therapeutic Objectives • Increase blood flow to ischemic heart muscle and/or • Decrease myocardial oxygen demand

  15. Antianginal Agents: Therapeutic Objectives • Minimize the frequency of attacks and decrease the duration and intensity of anginal pain • Improve the patient’s functional capacity with as few side effects as possible • Prevent or delay the worst possible outcome, MI

  16. Nitric Oxide Opie LH: Heart Physiology Lippincot Williams & Wilkins, 2004

  17. Antianginal Agents: Nitrates Available forms: Sublingual Ointments Buccal Transdermal patches Chewable tablets Inhalable sprays Capsules Intravenous solutions

  18. Antianginal Agents: Nitrates • Cause vasodilation due to relaxation of smooth muscles • Potent dilating effect on coronary arteries • Used for prophylaxis and treatment of angina

  19. Antianginal Agents: Nitrates Nitroglycerin • Prototypical nitrate • Large first-pass effect with PO forms • Used for symptomatic treatment of ischemic heart conditions (angina) • IV form used for BP control in perioperative hypertension, treatment of CHF, ischemic pain,and pulmonary edema associated with acute MI

  20. Antianginal Agents: Nitrates • isosorbide dinitrate (Isordil, Sorbitrate, Dilatrate SR) • isosorbide mononitrate (Imdur, Monoket, ISMO) Used for: • Acute relief of angina • Prophylaxis in situations that may provoke angina • Long-term prophylaxis of angina

  21. Antianginal Agents: Nitrates Side Effects • Headache • Usually diminish in intensity and frequency with continued use • Tachycardia, postural hypotension • Tolerance may develop

  22. Nitrate Tolerance • Occurs with chronic administration of long acting nitrates. • Efficacy of drug diminishes with chronic exposure (tachyphylaxis). • Tolerance readily reverses with nitrate free interval.

  23. Antianginal Agents: Beta Blockers • atenolol (Tenormin) • metoprolol (Lopressor) • propranolol (Inderal) • nadolol (Corgard)

  24. Adrenergic Receptors Beta1 • SA node, AV node, His-Purkinje system • Myocardium • Juxtaglomerular apparatus • Adipocytes Beta2 • Peripheral and coronary vasculature • Bronchi • Peripheral Muscle • Uterine Muscle Alpha • Peripheral circulation Beta-1 Beta-2 Alpha Adapted from Runge et al, Netter’s Cardiology

  25. Antianginal Agents: Beta Blockers Mechanism of Action • Decrease the HR, resulting in decreased myocardial oxygen demand and increased oxygen delivery to the heart • Decrease myocardial contractility, helping to conserve energy or decrease demand

  26. Antianginal Agents: Beta Blockers Therapeutic Uses • Antianginal • Antihypertensive • Cardioprotective effects, especially after MI

  27. Antianginal Agents: Beta Blockers Side Effects Body System Effects Cardiovascular bradycardia, hypotension second- or third-degree heart block heart failure Metabolic Altered glucose and lipid metabolism

  28. Antianginal Agents: Beta Blockers Side Effects Body System Effects CNS dizziness, fatigue, mental depression, lethargy, drowsiness, unusual dreams Other impotence wheezing, dyspnea

  29. Antianginal Agents: Calcium Channel Blockers • verapamil (Calan) • diltiazem (Cardizem) • nifedipine (Procardia)

  30. Role of Calcium Channels in Myocardial Contraction Opie LH, Heart Physiology, Williams Lippincott and Williams 2004

  31. Role of Calcium Channel in Vascular Smooth Muscle Function Opie LH, Heart Physiology, Williams Lippincott and Williams 2004

  32. Antianginal Agents: Calcium Channel Blockers Mechanism of Action • Cause peripheral arterial vasodilation • Reduce myocardial contractility (negative inotropic action) • Result: decreased myocardial oxygen demand

  33. Antianginal Agents: Calcium Channel Blockers Therapeutic Uses • First-line agents for treatment of angina, hypertension, and supraventricular tachycardia • Short-term management of atrial fibrillation and flutter • Several other uses

  34. Antianginal Agents: Calcium Channel Blockers Side Effects • Very acceptable side effect and safety profile • May cause hypotension, palpitations, tachycardia or bradycardia, constipation, nausea, dyspnea

  35. Treatment of Ischemic Heart Disease

  36. Antianginal Agents: Nursing Implications • Before administering, perform a complete health history to determine presence of conditions that may be contraindications for use or call for cautious use. • Obtain baseline VS, including respiratory patterns and rate. • Assess for drug interactions.

  37. Antianginal Agents: Nursing Implications • Patients should not take any medications, including OTC medications, without checking with the physician. • Patients should report blurred vision, persistent headache, dry mouth, dizziness, edema, fainting episodes, weight gain of 2 pounds in 1 day or 5 or more pounds in 1 week, pulse rates under 60, and any dyspnea.

  38. Antianginal Agents: Nursing Implications • Alcohol consumption and hot baths or spendingtime in jacuzzis, hot tubs, or saunas will result in vasodilation, hypotension, and the possibility of fainting. • Teach patients to change positions slowly to avoid postural BP changes. • Encourage patients to keep a record of their anginal attacks, including precipitating factors, number of pills taken, and therapeutic effects.

  39. Antianginal Agents: Nitroglycerin Nursing Implications • Instruct patients in proper technique and guidelines for taking sublingual NTG for anginal pain. • Instruct patients never to chew or swallow the SL form. • Instruct patients that a burning sensation felt with SL forms indicates that the drug is still potent.

  40. Antianginal Agents: Nitroglycerin Nursing Implications • Patients are taught to take up to three tablets every 5 minutes. If no relief from chest pain is obtained after three tablets, they should seek medical assistance. • Absorption nitroglycerin ointments best over a nonfatty and nonhairy portion of skin. The upper torso is the preferred site of application. The nurse should wear gloves when applying to prevent transdermal absorption by the applier. The ointment is measured as one straight line on the nitroglycerin patch and is gently spread over paper and applied, but not rubbed, into the skin.

  41. Antianginal Agents: Nitroglycerin Nursing Implications • Instruct patients to keep a fresh supply of NTG on hand; potency is lost in about 3 months after the bottle has been opened. • Medications should be stored in an airtight, dark glass bottle with a metal cap and no cotton filler to preserve potency.

  42. Antianginal Agents: Nitroglycerin Nursing Implications • Instruct patients in the proper application of nitrate topical ointments and transdermal forms, including site rotation and removal of old medication. • To reduce tolerance, the patient may be instructed to remove topical forms at bedtime, and apply new doses in the morning, allowing for a nitrate-free period.

  43. Antianginal Agents: Nitroglycerin Nursing Implications • Instruct patients to take prn nitrates at the first hint of anginal pain. • If experiencing chest pain, the patient taking SL NTG should be lying down to prevent or decrease dizziness and fainting that may occur due to hypotension. • Monitor VS frequently during acuteexacerbations of angina and during IV administration.

  44. Antianginal Agents: Nitroglycerin Nursing Implications • IV forms of NTG must be contained in glass IV bottles and must be given with infusion pumps. • Discard parenteral solution that is blue, green, or dark red. • Follow specific manufacturer’s instructions for IV administration. Use special IV tubing provided or non-PVC tubing.

  45. Antianginal Agents: Calcium Channel Blockers Nursing Implications • Blood levels should be monitored to ensure they are therapeutic. • Oral CCBs should be taken before meals and as ordered. • Patients should be encouraged to limit caffeine intake.

  46. Antianginal Agents: Beta Blockers Nursing Implications • Patients taking beta blockers should monitor pulse rate daily and report any rate lower than 60 beats per minute. • Dizziness or fainting should also be reported. • Constipation is a common problem. Instruct patients to take in adequate fluids and eat high-fiber foods.

  47. Antianginal Agents: Beta Blockers Nursing Implications • These medications should never be abruptly discontinued due to risk of rebound hypertensive crisis. • Inform patients that these medications are for long-term prevention of angina, not for immediate relief.

  48. Antianginal Agents: Nursing Implications • Monitor for adverse reactions • Allergic reactions, headache, light-headedness, hypotension, dizziness • Monitor for therapeutic effects • Relief of angina, decreased BP, or both

  49. Antidysrhythmic Agents

  50. Antidysrhythmics Dysrhythmia • Any deviation from the normal rhythm of the heart Antidysrhythmics • Drugs used for the treatment and prevention of disturbances in cardiac rhythm