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HF-ACTION

HF-ACTION. No difference in mortality/hospitalizations between the two arms (HR 0.93, 95% CI 0.84-1.02, p = 0.13). On adjustment for other prognostic factors, was ↓ in exercise training arm (p = 0.03)

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HF-ACTION

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  1. HF-ACTION No difference in mortality/hospitalizations between the two arms (HR 0.93, 95% CI 0.84-1.02, p = 0.13). On adjustment for other prognostic factors, was ↓ in exercise training arm (p = 0.03) CV mortality & CV hospitalizations (p = 0.14), 6-minute walk distance similar, but peak VO2 higher in the exercise training arm Serious side effects similar between two arms (p = 0.26) (p < 0.0001) Usual care (n = 1,172) Exercise training (n = 1,159) Trial design: Patients with symptomatic systolic CHF on optimal medical therapy were randomized to either exercise training or usual medical care. Clinical outcomes were compared at 3 years. Results 1.0 20 15 0.7 13 12 m 10 0.5 ml/min/kg 5 Conclusions 0.1 • Prescribed exercise training program in patients with systolic CHF safe and effective, when added on to optimal medical therapy • Strengthens current recommendations for exercise in CHF patients 0 0 Change in 6-minute walk distance Change in Peak VO2 O’Connor CM, et al. JAMA 2009;301:1439-50

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