1 / 25

Protein turnover . Biosynthesis of a mino acids

Protein turnover . Biosynthesis of a mino acids. Léránt István. Biosynthesis of amino acids. N – NH 4 + C – glycolysis , PPP, citric acid cycle L-amino acid / D –amino acid Proteinog e n amino acids 20 (22) Essential amino acids Non essential amino acids. NADPH – L-Glutam a t e.

riona
Télécharger la présentation

Protein turnover . Biosynthesis of a mino acids

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Protein turnover.Biosynthesis of amino acids Léránt István

  2. Biosynthesis of amino acids N – NH4+ C – glycolysis, PPP, citric acid cycle L-aminoacid/ D –amino acid Proteinogen amino acids 20 (22) Essential amino acids Non essential amino acids

  3. NADPH – L-Glutamate

  4. Glutaminesynthetase

  5. Synthesis of amino acids Origin of C Intermedier of glycolysis Intermedier of PPP Intermedier of citric acid cycle

  6. BIOSYNTHESIS OF AMINO ACIDS • alpha-ketoacidà alpha-amino acid Asp Ala Glu

  7. SYNTHESIS OF AMINO ACIDS Asp Ala Glu

  8. SYNTHESIS OF AMINO ACIDS • Transamination • Deamination • Decarboxylation • Glycogen-glucose PLP – Vitamin B6

  9. Glutamate SYNTHESIS OF AMINO ACIDS Glutamate-g-semialdehyde Proline Arginine Proline Arginine

  10. Glutamate SYNTHESIS OF AMINO ACIDS Glutamate-g-semialdehyde Prolin Arginin Proline Ornitine Arginine

  11. SYNTHESIS OF AMINO ACIDS Ser Glycolysis intermedier: 3-P-glycerate Transamination Dephosphorylation Ser: precursor of Gly & Cys

  12. SYNTHESIS OF AMINO ACIDS Ser Ser: precursor of Gly & Cys Ser Gly

  13. SYNTHESIS OF AMINO ACIDS Ser Ser: precursor of Gly & Cys Ser + homocysteine (Met) Cystationine Alpha-ketobutyrate + cysteine

  14. FOLIC ACID – C1 • Vitamin B9, Vitamin M • Vitamin B9 deficiency • megaloblastic anaemia • Neurological symptoms peripherial neuropathy myelopathy • vegetative disturbance • psychiatric disturbance • depression • insomnia • irritability • forgetfulness Folium Spinach 15 mg / adults Mainly - liver

More Related