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Central Dogma (for your disease?)

Central Dogma (for your disease?). LB 145 February 22-23, 2011. Deoxyribonucleic Acid. Protein (short protein called peptide). Protein =Amino Acids stuck together By what kind of bond? What kind of reaction is this?. From Gene to Peptide. Functional Peptide: PROTEIN. DNA. 1.

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Central Dogma (for your disease?)

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  1. CentralDogma(for your disease?) LB 145 February 22-23, 2011

  2. Deoxyribonucleic Acid

  3. Protein (short protein called peptide) • Protein =Amino Acids stuck together • By what kind of bond? • What kind of reaction is this?

  4. From Gene to Peptide Functional Peptide: PROTEIN

  5. DNA 1 Synthesis of mRNA in the nucleus mRNA NUCLEUS CYTOPLASM

  6. DNA 1 Synthesis of mRNA in the nucleus mRNA NUCLEUS CYTOPLASM mRNA 2 Movement of mRNA into cytoplasm via nuclear pore

  7. DNA 1 Synthesis of mRNA in the nucleus mRNA NUCLEUS CYTOPLASM mRNA 2 Movement of mRNA into cytoplasm via nuclear pore Ribosome 3 Synthesis of protein Amino acids Polypeptide

  8. The CFTR gene is 189,000 bases long • There are 27 exons/ 26 introns in it. • The mRNA (all exons) is 6129 bases • How many codons is that, max? • The protein is 1480 amino acids long • Normally it’s a Cl- channel, the mutation? Cystic Fibrosis is most often caused by mutation DF508 in the CFTR gene

  9. What do you know of your disease’s Central Dogma? • What is the size of your gene? • How many exons/introns does it have? • What is the size of your mRNA (cDNA)? • How many codons does it have? • What is the size of your protein? • What is the normal vs abnormal function of it?

  10. Reminders • Peer Review DUE • Might want to look over the criticisms soon-ish • Order your primers by 5pm FRIDAY • Check ATCC.org for cells and DNA.

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