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IL-12 TNF- α IL-1 GM-CSF

CD4 + T cell. activation. CD4. CD28 or CD152. T cell receptor. CD80/86. peptide. MHC class I. T cell receptor. ER. CD8. MHC class II. peptide. ?. Internalisation of exogenous antigen. CD8 + T cell. TAP. Antigen-specific. Induction of maturation  MHC Class I/II expression

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IL-12 TNF- α IL-1 GM-CSF

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  1. CD4+T cell activation CD4 CD28 or CD152 T cell receptor CD80/86 peptide MHC class I T cell receptor ER CD8 MHC class II peptide ? Internalisation of exogenous antigen CD8+ T cell TAP Antigen-specific Induction of maturation  MHC Class I/II expression  CD80/86 (B7) expression  ICAM-1 expression Antigen non-specific CD80 or CD86 CD28 or CD152 activation MHC class II Induction/secretion of cytokines ICAM-1 Dendritic Cell IL-12 TNF-α IL-1 GM-CSF Figure 1

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