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Antibacterial Handwashes: Formulations with Antimicrobial Persistence

Antibacterial Handwashes: Formulations with Antimicrobial Persistence. Lawton Seal, PhD Sr. Program Manager Healthpoint R&D. Antibacterial Handwashes.

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Antibacterial Handwashes: Formulations with Antimicrobial Persistence

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  1. Antibacterial Handwashes:Formulations with Antimicrobial Persistence Lawton Seal, PhD Sr. Program Manager Healthpoint R&D

  2. Antibacterial Handwashes • Consumer products for hand antisepsis are not routinely formulated to provide antimicrobial persistence or residual effects, allowing for relative rapid re-growth of flora • Therefore, frequent product applications are needed to maintain some degree of hand antisepsis • Alcohol-based formulations can be produced that provide prolonged antimicrobial action, may be used with or without water, and do not overtly damage the skin • Given the importance of this product indication to the general public, we tested to ensure appropriate efficacy

  3. Testing Methods • Supporting data was obtained employing the following test methods: • Tentative Final Monograph in vivo test for Health Care Personnel Handwash (HCPHW) • 5-day in vivo persistence assay: • Similar concept to surgical scrub test • Washout for 7 days and baseline assessments • Four daily product applications (in an hour) per product instructions • Application times varied • Subjects gloved • Post-application samples at 1 min, 4 hrs, and 8 hrs • Both water-aided and waterless product applications were tested • Results published: Am J Infect Control 2005:33:207-216.

  4. Waterless ProductsTFM in vivo HCPHW Test Am J Infect Control 2005:33:207-216

  5. Waterless Products5-day in vivo Persistence Test Am J Infect Control 2005:33:207-216

  6. Water-aided Products TFM in vivo HCPHW Test Am J Infect Control 2005:33:207-216

  7. Water-aided Products5-day in vivo Persistence Test Am J Infect Control 2005:33:207-216

  8. Conclusions • These data support our assertion that antimicrobial persistence is available to the consumer • A TFM-like test should be employed for these consumer products • Thus provide adequate information about the level and duration of antimicrobial action

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