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John Walker – Martin Montgomery

Mitochondria – ATP Synthase. John Walker – Martin Montgomery. In your body the electric motor enzyme ATP Synthase driven by protons – not electrons – catalyses the reaction: ADP + P → ATP. A protons neutralise negatively charged groups on the stator causing it to turn. www.bioc.aecom.yu.edu.

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John Walker – Martin Montgomery

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  1. Mitochondria – ATP Synthase John Walker – Martin Montgomery

  2. In your body the electric motor enzyme ATP Synthase driven by protons – not electrons – catalyses the reaction: ADP + P → ATP

  3. A protons neutralise negatively charged groups on the stator causing it to turn

  4. www.bioc.aecom.yu.edu

  5. A rotating central spindle opens and closes the cavity gaps allowing ADP and P in and ATP out

  6. http://en.wikipedia.org/wiki/ATP_synthase

  7. Meccano Clockwork Motor

  8. Hornby Metropolitan Londom Subway Engine

  9. ATP synthase (EC3.6.3.14) is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate (ATP). ATP is the most commonly used "energy currency" of cells from most organisms. It is formed from adenosine diphosphate (ADP) and inorganic phosphate (Pi), and needs energy. The overall reaction sequence is: ATP synthase + ADP + Pi → ATP Synthase + ATP Energy is often released in the form of protium or H+, moving down an electrochemical gradient, such as from the lumen into the stroma of chloroplasts or from the inter-membrane space into the matrix in mitochondria.

  10. rotating spindle opens and closes the cavities

  11. ADP + P enter

  12. A protons neutralise negatively charged groups on the stator causing it to turn

  13. ATP ejected

  14. An electric motor driven by protons in water !

  15. ADP and P enter the cavities and combine to form ATP Central rotating spindle opens and closes the cavities to allow ADP to enter and ATP to escape ATP ejected A protons neutralise negatively charged groups on the stator causing it to turn – this is a real electric motor – driven by protons – NB in aqueous media!!!!

  16. Balmoos and Dimroth This is a real electric motor – driven by protons (not electrons) – NB in water !!!! Paul Boyer and John Walker

  17. ATP ejected ADP + Pi enter cavity rotating spindle opens and closes the cavities Protons neutralise –velycharged moiety on rotor causing rotor to rotate 30o

  18. ATP Synthase Paul Boyer John Walker

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