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Metrics of Success, Version 2: An Example – Neonatal Sepsis

Metrics of Success, Version 2: An Example – Neonatal Sepsis. Evaluating the Impact of Research Facilitated by CTSAs on Important Child Health Problems. 1. Identify an important child health problem. 47% early onset; 53% late-onset. 47% early onset; 53% late-onset.

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Metrics of Success, Version 2: An Example – Neonatal Sepsis

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  1. Metrics of Success,Version 2:An Example – Neonatal Sepsis Evaluating the Impact of Research Facilitated by CTSAs on Important Child Health Problems

  2. 1. Identify an important child health problem 47% early onset; 53% late-onset 47% early onset; 53% late-onset http://www.cdc.gov/NCHS/data/dvs/LCWK7__2004.pdf

  3. 2. Identify one or more metrics that quantify the problem and can track progress over time – 1 Incidence of Early- & Late-Onset Invasive Group B Streptococcal Infection Active Bacterial Core (ABC) Surveillance System Centers for Diseases Control and Prevention MMWR 2005;54:1205-8

  4. 2. Identify one or more metrics that quantify the problem and can track progress over time – 2 Incidence of Early-Onset Infections in Very Low Birthweight Infants NICHD Neonatal Network Stoll BJ, et al. Pediatrics 2011;127:817-26

  5. 3. Identify historic advances and their impact on the problem Prenatal Screening for Colonization and Intrapartum Antimicrobial Prophylaxis Have Decreased the Incidence of Early-Onset Invasive Group B Streptococcal Infections Schrag SJ, et al. N Engl J Med 2000;342:15-20

  6. 4. Identify gaps in knowledge and barriers to improved diagnosis, treatment and prevention – 1 Incidence of Late-Onset Invasive Group B Streptococcal Infections Remains Unchanged MMWR 2005;54:1205-8

  7. 4. Identify gaps in knowledge and barriers to improved diagnosis, treatment and prevention – 2 Incidence of Early-Onset Invasive Gram Negative Infections Remains Unchanged Stoll BJ, et al. Pediatrics 2011;127:817-26

  8. Absolute Neutrophil Count White Blood Cell Count 4. Identify gaps in knowledge and barriers to improved diagnosis, treatment and prevention – 3 Biomarkers (e.g., Complete Blood Count) Do Not Identify Infants with Sepsis with Sufficient Accuracy Shortly After Birth Newman TB, et al. Pediatrics 2010;126:903-9

  9. 4. Identify gaps in knowledge and barriers to improved diagnosis, treatment and prevention – 4 Gaps in Screening and Administration of Intrapartum Antimicrobial Prophylaxis for Early-Onset Group B Streptococcal Infection Remain CDC. MMWR 2010;59(RR-10):11

  10. 4. Identify gaps in knowledge and barriers to improved diagnosis, treatment and prevention – 5 Racial Disparities in the Incidence of Early-Onset Group B Streptococcal Infection Remain MMWR 2009;58:109-12

  11. 5.Identify grants, programs, initiatives, and collaborative networks addressing these gaps and their connections to CTSA institutions & the Consortium, NCATS and other Institutes/Centers, other federal agencies, etc. A Search of “Neonatal Sepsis” Using NIH RePORT Identified Two Multi-Center Networks and Numerous Individual Grants How Many of These Projects are Being Facilitated by CTSAs? • NICHD Neonatal Research Network • NICHD Maternal Fetal Medicine Units Network • <100 R01, R21, R03, R44s and K-awards at NICHD, NIAID, NINR and NIGMS 6.Track the linkage between these grants/programs/initiatives/networks and future reseach advances 7.Evaluate the impact of future research advances on metrics that quantify the problem over time

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