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Narrowing the Diameter of Electrospun Nanofibres

Narrowing the Diameter of Electrospun Nanofibres. Wai Hei Tse The University of Western Ontario Department of Medical Biophysics April 7, 2010. Table of Contents. Introduction Electrospinning Nanofibers Materials Collagen Polycaprolactone (PCL) Applications Results Conclusions.

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Narrowing the Diameter of Electrospun Nanofibres

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  1. Narrowing the Diameter of ElectrospunNanofibres Wai Hei Tse The University of Western Ontario Department of Medical Biophysics April 7, 2010

  2. Table of Contents • Introduction • Electrospinning • Nanofibers • Materials • Collagen • Polycaprolactone (PCL) • Applications • Results • Conclusions

  3. Introduction • Electrospinning: process in which solid fibres are produced from a polymeric solution • Based on electrostatic charge repulsion and fluid properties • Objective: Narrow electrospunnanofibres to a consistent diameter of 100-250 nm.

  4. Why nanoscale? Why not larger?

  5. Why Collagen and Polycaprolactone? • Biocompatibility • Cost-effective for large scale electrospinning

  6. Applications PCL Fibres (Patcharaporn, W., et al. 2005) Collagen Scaffold (Mekhail, M. 2009)

  7. Electrospinning Apparatus Nanotechweb.org

  8. Theory • Taylor Cone (Doshi, J., and Reneker, D. H.) • Electrosplaying(Thompson, C.J., et al.) ThePedia.com

  9. Results Inconsistent Diameter of Nanofibres(Erica Lee)

  10. Results cont’d Objective! Beading of PCL Nanofibre(Erica Lee) Consistent PCL Fibres (Erica Lee)

  11. Conclusion • Flow rate and electric field gradient are the most important factors in determining the fibre diameter • The resultant fibre diameter is relative to the contributing factors Future Investigation • Reduce surface tension with additives • Increase volumetric charge density with salts • Co-axial Spinning

  12. Acknowledgements • Dr. Wankei Wan • Department of Chemical and Biochemical Engineering • Dr. Martin Zinke-Allmang • Department of Medical Biophyiscs • Erica Lee • M. E. Sc. Candidate; Biomedical Engineering

  13. Questions?

  14. Method • 12% PCL solution by weight • Dissolved in tetrafluoroethylene (TFE) Nanotechweb.org

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