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Parkinson's Disease

Parkinson's Disease. Animal Models and Possible Treatments. What is an animal model?. What is an animal model? A laboratory animal used in research that simulates processes comparible to those that occur in humans. Lab rats. Two common animal models. Lab rats. Vertebrate model

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Parkinson's Disease

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  1. Parkinson's Disease Animal Models and Possible Treatments.

  2. What is an animal model?

  3. What is an animal model?A laboratory animal used in research that simulates processes comparible to those that occur in humans.

  4. Lab rats. Two common animal models.

  5. Lab rats. Vertebrate model Somehow resistant to MPTP Two common animal models.

  6. Lab rats. Vertebrate model Somehow resistant to MPTP Rotenone administered systemically - Chronic nigrostriatal cell loss, dopamine depletion,  Akinesia, rigidity, tremor, flexed posture, piloerection. Two common animal models.

  7. Lab rats. Vertebrate model Somehow resistant to MPTP Rotenone administered systemically - Chronic nigrostriatal cell loss, dopamine depletion,  Akinesia, rigidity, tremor, flexed posture, piloerection. Fruit flies. Invertebrate model Two common animal models.

  8. Lab rats. Vertebrate model Somehow resistant to MPTP Rotenone administered systemically - Chronic nigrostriatal cell loss, dopamine depletion,  Akinesia, rigidity, tremor, flexed posture, piloerection. Fruit flies. Invertebrate model Dopamine is depleted. But is reversible by Hsp70 coexpression. Is there any use for this in human model? Two common animal models.

  9. Any similarities?

  10. Possible treatments...

  11. Possible treatments... No two patients  have the same experience of Parkinson's disease, and so any treatment given must suit the individual.

  12. Possible treatments... No two patients  have the same experience of Parkinson's disease, and so any treatment given must suit the individual. You must consider - 

  13. Possible treatments... No two patients  have the same experience of Parkinson's disease, and so any treatment given must suit the individual. You must consider -  Age                                   Lifestyle                                   Personal Preference                                    etc.

  14. Drug treatments...

  15. Drug treatments... Levodopa Taken in by dopaminergic neuron terminals and converted to dopamine. Only 1% reaches the brain if dose is metabolised. Side effects - Nausea, Vomiting                           Anorexia                           Postural hypotension                           Involuntary movement                           Urine discolouration   

  16. Drug treatments... Enyme inhibitors Inhibits enzyme which breaks down dopamine (MAOB), prolonging the effect of remaining dopamine in the brain. Side effects - Sleep disorders                           Vertigo                           Dry mouth                           Skin rash                           Depression 

  17. Drug treatments... Dopamine agonists Mimic natural dopamine by stimulating dopamine receptors in the brain. Side effects - Nausea, vomiting                           Dizziness                           Headache                           Sudden sleep (patients can't drive)                           Hallucinations

  18. Surgery... Deep Brain Stimulation (DBS) Reduces distressing symptoms such as rigidity. Tiny wire electrodes are implanted in the Basal Ganglia. They are connected to an Implantable Pulse Generator in the chest. Turn pulse on:      symptoms reduce. Turn pulse off:    symptoms return. Cost €40,000 to €50,000! Ideal candidates are younger and fit. Must have no history of severe depression.

  19. What does the future hold?

  20. What does the future hold? Stem cell research... Scottich scientists are creating dopamine-producing neural cells. These can be injected into patients brain to reverse the effects of Parkinson's. BUT   -   Will the injected cells be accepted by the patient?                Or will they be destroyed in a natural immune response. This research is ongoing. It may take 20 years before it is ready for widespread use.

  21. References Betarbet, et al. Nat Neurosci 2000; (12):1301-6. Parkinson's disease A nurse's handbook 2008. http://news.scotsman.com/

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