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Dengue Virus Virus, Epidemiology (Aedes aegypti vector)

In search of Dengue Biomarkers Student: Maike-Svenja Milkereit - Supervisor: Dr. Brian Ward, Montréal General Hospital. Dengue Virus Virus, Epidemiology (Aedes aegypti vector) Dengue Fever (DF) versus Dengue Hemorrhagic Fever (DHF)

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Dengue Virus Virus, Epidemiology (Aedes aegypti vector)

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  1. In search of Dengue BiomarkersStudent: Maike-Svenja Milkereit - Supervisor: Dr. Brian Ward, Montréal General Hospital • Dengue Virus Virus, Epidemiology (Aedes aegypti vector) • Dengue Fever (DF) versus Dengue Hemorrhagic Fever (DHF) • Hypothesis Plasma biomarkers exist that can distinguish between DF and DHF early in disease progression • In search of…. Biomarkers = Prognostic Tools = Understanding Disease Pathogenesis

  2. In search of Dengue Biomarkers • Samples: • Disease (1o/2o, DF/DHF, time point collected, viral serotype) • Control • Tools: • SELDI-TOF MS • CE & BPS Analysis • Biochemistry (Fractionations & Gels) • Protein ID • Biomarker Validation • Experiments Investigating Biomarker Role in Pathogenesis Candidate Biomarkers ?

  3. In search of Dengue Biomarkers SELDI-TOF MS Spectra of Dengue Patient Plasma Sample (#35, 1DHFt1) • Expected Results: • Candidate Biomarkers distinguishing DF/DHF/Control • Biomarker Identity: Host protein? Immunoregulatory? Affecting Vascular Endothelia? Signal Intensity M/Z Thank-you!

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