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Advancements and Future Directions in PAH Therapy: Lessons and Challenges

This comprehensive review explores the current landscape of pulmonary arterial hypertension (PAH) therapy, including historical developments in left heart failure treatments and insights into right ventricular structure and function. Key topics cover the evolution of endpoint-driven clinical trials, challenges faced in trial design, and the role of combination therapies in managing PAH. The synthesis of findings from registries like REVEAL and the implications of immune response dysregulation provide a roadmap for future research and treatment strategies aimed at improving patient outcomes.

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Advancements and Future Directions in PAH Therapy: Lessons and Challenges

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  1. Setting the Stage – PAH Therapy Trials

  2. Current PAH Pharmacotherapies

  3. History of LHF Therapy

  4. Disease Modification in LHF

  5. HFrEF Lessons Learned – Moving Forward in PAH

  6. RV Structure and Function in PH – The Downward Spiral

  7. Growth and Immune Response Dysregulation in PAH

  8. RV Function in PAH

  9. Lessons From HFpEFRV-PA and RV-LV Interactions

  10. Right Heart and Survival in PAH – REVEAL Registry Data

  11. RV-PA and RV-LV Interactions

  12. Evolution of End Point-Driven Trials in PAH

  13. Current and Future Challenges in End Point Design

  14. Right Heart vs Left Heart Therapies

  15. Designing PAH Trials – The Next Steps

  16. Combination Therapy in PAH

  17. Combination Therapy in PAH (cont)

  18. Conclusion

  19. Abbreviations

  20. Abbreviations (cont)

  21. References

  22. References (cont)

  23. References (cont)

  24. References (cont)

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