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Pyrimidinsynthese

Learn about the intricate steps involved in pyrimidine synthesis, including the roles of ATP, glutamine, carbamoyl phosphate, and more. Explore the key intermediates and enzymes in this essential metabolic pathway.

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Pyrimidinsynthese

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  1. Pyrimidinsynthese

  2. ATP O +NH3 C CH2 CH2 COO- H2N C C HO O O O H CH2 +NH3 C P CH2 -OOC CH2 CH2 COO- C C H O O + O H O H3N C C H P O O O C O O +NH3 -OOC CH2 COO- C H W. Storch, D. Doenecke Glutamin Glutamat HO H2N O + H3N C HO O O ADP ADP Carbamoyl phosphat Carbamoylsäure Carboxyphosphat Bicarbonat Aspartat

  3. Q O H2O P O N O O QH2 H2N P C HO O HO N O O C H O O C HO H2 H CH2 CH C H + H3N O C Carbamoylaspartat Dihydroorotat Orotat O

  4. ATP H+ O C O O O O O P P P P P P O O O HO OH O C O C O O O O O O HO OH P P CO2 O O OH O O H N C C O CH C N H H Orotat OMP UMP UDP UTP 5-Phosphoribosyl-1-pyrophosphat (PRPP) ADP ADP

  5. ATP +NH3 +NH3 P P P P P P C -OOC CH2 CH2 COO- H2N C C CH2 CH2 COO- H H O O N C H C O CH O O C C C N O O H N C H O O HO HO OH OH C O CH P UTP O O C N H Glutamin Glutamat H2N O ADP UTP CTP

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