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Dynamic interactive nanosystems and nanoreservoirs

This presentation by Phillip Hayes outlines his academic and personal journey in chemistry and explores innovative research directions in dynamic interactive nanosystems. It covers previous project work, including the synthesis of marine sponge alkaloids, and describes the current focus on guanidinium-based phosphate recognition platforms and G-quadruplex ligands. The aim is to develop functional nanomaterials for DNA recognition and create nanoreservoir systems for small molecule binding. The presentation encourages collaboration and idea generation in cutting-edge nanoscience applications.

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Dynamic interactive nanosystems and nanoreservoirs

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  1. Dynamic interactive nanosystems and nanoreservoirs Phillip Hayes

  2. Presentationaims • My background • Academic & personal • Previouschemistryprojectwork (Quick overview) • Outlineaims and research directions for dynano • Initial lines of enquiry • Guanidiniumbased phosphate recognition platforms. • G Quadruplex ligands and support structures • Possible applications / direction of work • Generateideas and research direction

  3. Introduction

  4. Previouswork Leftschool – worked in insurance Cricket in Australia Undergraduatestudiesat Manchester MetropolitanUniversity

  5. Introduction

  6. Halichlorine • Undergraduate project – organic synthesis • Marine sponge alkaloid • Harvested in minute quantities • Desirable target for synthesis

  7. Biological significance Inflammatory response VCAM-1 Metastatic processes Atherosclerosis Hepatitis C

  8. Syntheticaims Library of derviative compounds Retainbiologicalactivity Ease of synthesis

  9. Dynamic interactive nanosystems and nanoreservoirs Objectives • Synthesiselibraries of compounds that have potential DNA / G Quadruplex bindingcapabilities • Developfunctionalnanomaterials capable of DNA recognition properties, usingConstitutionalDynamicChemistry. • Developnanoreservoirsystems capable of smallmoleculebinding for QCM signal amplification

  10. Line of inquiry 1 – Phosphate recognition

  11. Guanidinium recognition

  12. DNA / G Quadruplex recognition • Shape dependentupon how G quartets stack. • Loop structure varies – parallel or anti-parallel looping

  13. G Quadruplex Ligands • Ligands bindstrongly to stabilise the G Quadruplex structure • Show preferentialaffinity for certain quadruplex loop structures • Createlibraries of moleculescontainingfunctionalitiessimilar to moleculesshown. • Ligand withmost stable affinity – express itself.

  14. G Quadruplex – potentialmembers of library

  15. DNA / G Quartet recognition – support structure

  16. Possible applications

  17. ~ QCM signal amplification _ DNA recognition platforms

  18. Presentationaims • My background • Academic & personal • Previouschemistryprojectwork • Outlineaims and research directions for dynano • Initial lines of enquiry • Guanidiniumbased phosphate recognition platforms. • G Quadruplex ligands and support structures • Possible applications / direction of work • Generateideas and research direction

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