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The Relationship Between Lipoproteina and the Complications of Diabetes Mellitus M.L Koschinsky. S.M. Marcovina. Acta D

Abstract. Risk of CV disease increased 2-4 fold in DM ptTraditional risk factors can't completely explainedNon-diabetic studies demonstrated elevated Lp(a) and risk of atherosclerotic disordersRole of lipoprotein(a) in DM CV disease ?. Controversial questions. Plasma Lp(a) levels and phenotype

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The Relationship Between Lipoproteina and the Complications of Diabetes Mellitus M.L Koschinsky. S.M. Marcovina. Acta D

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    1. The Relationship Between Lipoprotein(a) and the Complications of Diabetes Mellitus M.L Koschinsky. S.M. Marcovina. Acta Diabetol (2003) 40:65-76 ?????? ???????? ?????

    2. Abstract Risk of CV disease increased 2-4 fold in DM pt Traditional risk factors can’t completely explained Non-diabetic studies demonstrated elevated Lp(a) and risk of atherosclerotic disorders Role of lipoprotein(a) in DM CV disease ?

    3. Controversial questions Plasma Lp(a) levels and phenotype distributions altered in type 1 and type 2 DM ? Does the degree of metabolic control influence Lp(a) levels in these pt? What is the relationship between Lp(a) and renal disease? Do increased Lp(a) conc in DM pt contribute to the vascular complications? Can the atherogenicity of Lp(a) in DM be enhanced in the absence of elevated levels of this lipoprotein due to bochemical modifications?

    4. Introduction DM pt have 2-4 fold increased risk of developing CV disease Traditional risk factors-hypertension, dyslipidemias-can’t completely account for the increase burden of CV disease Level of metabolic control also does not appear to be a major contributing factor

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