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Cell cycle (Cell division), Cell-cell interaction, growth and their control Aging

Core Course # MM 704 (Cellular and Molecular Pathology). Cell cycle (Cell division), Cell-cell interaction, growth and their control Aging Apoptosis Tissue injury and repair mechanisms Cell regenerating potential (Role of Stem Cells) Mediators, modulators and messengers

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Cell cycle (Cell division), Cell-cell interaction, growth and their control Aging

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  1. Core Course # MM 704 (Cellular and Molecular Pathology) • Cell cycle (Cell division), Cell-cell interaction, growth and their control • Aging • Apoptosis • Tissue injury and repair mechanisms • Cell regenerating potential (Role of Stem Cells) • Mediators, modulators and messengers • Antioxidants in health and disease

  2. Induced differentiation of stem cells by small moleculesStrategies to enhance regenerative potential of stem cells

  3. Induced differentiation of stem cells by small molecules

  4. Direct Differentiation of ES Cells

  5. Direct Differentiation of MSCs

  6. Small Molecules and Cardiac Differentiation Dexamethasone Ascorbic acid 5-azacytidine Zebularine Retinoic acid Nitric oxide Difluoromethylornithine (DFMO)

  7. Differentiation of the Adult Stem Cells into Cardiac like cells by Small Molecules Zebularine

  8. Differentiation of the Adult Stem Cells into Cardiac like cells by Small Molecules Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755-5922.2012.00320.x

  9. Differentiation of the Adult Stem Cells into Cardiac like cells by Small Molecules Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755-5922.2012.00320.x

  10. Differentiation of the Adult Stem Cells into Cardiac like cells by Small Molecules Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755-5922.2012.00320.x

  11. Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755-5922.2012.00320.x

  12. Strategies to enhance regenerative potential of stem cells

  13. (a) Hypoxic Preconditioning

  14. After Hypoxia Before Hypoxia After Reoxygenation

  15. (b) Genetic Manipulation • e.g. Viral mediated

  16. Engineered MSCs transdifferentiate into CMs Circulation Res. Vol 99, 776-84. 2006

  17. Transplantation of Modified Stem Cells

  18. Myocardial infarction Blocked blood vessel Heart Attack Dead muscle Scar tissue

  19. Cell Transplantation Rat Infarction Model in Rats Isolation of Mesenchymal Stem Cells from rats Chemical or Genetic Modification Cell Transplantation Functional Studies Histology

  20. Circulation Res. Vol 99, 776-784. 2006

  21. References Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755 5922.2012.00320.x Circulation Res. Vol 99, 776-84. 2006

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