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Diabetes Mellitus Impact on Biomarker Correlations in Osteoarthritis

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Study on correlations between biomarkers and collagen crosslinks in osteoarthritis patients with and without diabetes mellitus, revealing complexities in the disease process.

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Diabetes Mellitus Impact on Biomarker Correlations in Osteoarthritis

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  1. Figure 4. Correlations between biomarkers and collagen crosslinks that differed between diabetes mellitus (DM) and non-DM groups. (a) Bone alkaline phosphatase (BAP) levels in serum were positively correlated to cartilage hydroxylysylpyridinoline (HP) in non-DM group, but negative in DM group. (b) Osteocalcin (OCN) levels in synovial fluid were not correlated to cartilage pentosidine in non-DM group, but were negatively correlated to cartilage pentosidine in DM group. (c) OCN levels in synovial fluid were not correlated to bone pentosidine in non-DM group, but were negatively correlated to bone pentosidine in DM group. Black filled circles represent DM group, and light gray filled circles represent non- DM group. Regression lines are indicated with dashed black line for DM group and solid gray line for non-DM group. Oren TW, Botolin S, Williams A, Bucknell A, King KB. Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes. J Rehabil Res Dev. 2011;48(10):1195–1210.DOI:10.1682/JRRD.2010.09.0186

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