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HIF1A

EGLN 1/2/3. miR-338/338-3p; miR-18ab; miR-135; miR-155 ; miR-17-5p/20 /93.mr/ 106 /519.d; miR-203; miR-194; miR-138; miR-199/199-5p; miR-19; miR-217. Normoxia. Hypoxia. VHL. TCEB1. TCEB2. HIF1B. CUL2. HIF1A. RBX1. CBP. EP300. O 2.

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HIF1A

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  1. EGLN 1/2/3 miR-338/338-3p; miR-18ab; miR-135; miR-155; miR-17-5p/20/93.mr/106/519.d; miR-203; miR-194; miR-138; miR-199/199-5p; miR-19; miR-217 Normoxia Hypoxia VHL TCEB1 TCEB2 HIF1B CUL2 HIF1A RBX1 CBP EP300 O2 miR-455/455-5p; miR-221/222; miR-383; miR-140/140-5p/876-3p; miR-103/107; miR-193ab; miR-23ab; miR-132/212; miR-150; miR-129/129-5p; miR-216/216a; miR-29abc; miR-9; miR-15/16/195/424/497; miR-490/490-3p; miR-10; miR-135; miR-7/7ab; miR-153; miR-139-5p; miR-26ab/1297; miR-18ab; miR-143 EGLN1: miR-200bc/429; miR-17-5p/20/93.mr/106/519.d; miR-21/590-5p; miR-106/302; miR-15/16/195/424/497; miR-143; miR-203; miR-132/212; miR-137 EGLN2: miR-23ab; miR-133; miR-15/16/195/424/497; miR-503; miR-18ab; let-7/98; miR-193ab EGLN3: miR-218; miR-7/7ab; miR-200bc/429; miR-31; miR-33/33ab; miR-17-5p/20/93.mr/106/519.d; miR-425/489; miR-130/301; miR-451; miR-182; miR-140/140-5p/876-3p; miR-122; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-9; miR-146; miR-129/129-5p; miR-128; miR-217 miR-129/129-5p; miR-132/212; miR-150; miR-26ab/1297; miR-138; miR-200bc/429; miR-148/152; miR-22; miR-96/1271; miR-17-5p/20/93.mr/106/519.d; miR-217; miR-182; miR-27ab miR-23ab; miR-191; miR-26ab/1297; miR-153; miR-200bc/429; miR-33/33ab; miR-490/490-3p; miR-129/129-5p; miR-130/301; miR-214/761; miR-194; miR-24; miR-17-5p/20/93.mr/106/519.d; miR-138; miR-106/302; miR-218 VHL: miR-204/211; miR-143; miR-101; miR-21/590-5p; miR-223; miR-129/129-5p; miR-216/216a; miR-23ab; miR-17-5p/20/93.mr/106/519.d; miR-141/200a; miR-1/206; miR-200bc/429; miR-132/212; miR-219/219-5p; miR-24; miR-499/499-5p; miR-208/208ab; miR-31; miR-375; miR-122; miR-150 TCEB1: miR-200bc/429; miR-217; miR-132/212 TCEB2: miR-216/216b; miR-150; miR-125/351; miR-204/211; miR-15/16/195/424/497; miR-214/761; miR-135; miR-22 Rbx1: miR-214/761; miR-194; miR-135; miR-7/7ab Cul2: miR-15/16/195/424/497; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-203 Degradation Transcriptional activity Supplemental Figure 2. Overview of VHL signaling. Summary of VHL signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in renal cell carcinoma are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplemental Table 3.

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