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CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343

NRMT methylates many targets, including SET ? and RB. CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343.

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CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343

Substrate recognition motif of NRMT. CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343.

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CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343

Mettl11a is the ? -N-RCC1 methyltransferase (NRMT). CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343.

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CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343

Silencing NRMT reduces RCC1 association with chromatin, and increases frequency of mitotic defects. CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343.

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1038 nature0 9343 - PowerPoint PPT Presentation

CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343

CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343

CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343

CES Tooley et al . Nature 000 , 1 - 4 (2010) doi:10.1038/nature0 9343