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Synthesis and anti-bacterial, anti-fungal activity of novel 1,2,4-oxadiazole

Synthesis and anti-bacterial, anti-fungal activity of novel 1,2,4-oxadiazole

A series of novel 1, 2, 4-oxadiazole derivatives were synthesized and evaluated for in- vitro antibacterial and antifungal activity. All the compounds tested against bacteria showed comparable or less antibacterial activities than the reference drug. Differences in their activity depend on the substitution of different groups. More specifically, best antibacterial activityamong synthetic analogues was shown by compound 6 with MIC of 10 µg/ml and compound 14 with MIC of 50 µg/ml against Bacillus subtilis. All compounds tested showed significant antifungal activity against all the fungi, compared to the commercial fungicide Miconazole. Among them compounds 4 and 8 showed good antifungal activity against Fusarium solani with MIC of 10 and 50 µg/ml.

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128 views • 10 slides
Synthesis and antimicrobial studies of 2-(5-substituted)-1, 3, 4- oxadiazole-2-yl)-H-imidazo [1, 2, α] pyridine derivat

Synthesis and antimicrobial studies of 2-(5-substituted)-1, 3, 4- oxadiazole-2-yl)-H-imidazo [1, 2, α] pyridine derivat

A novel series of 2-(5-substituted)-1,3,4-oxadiazole-2-yl)-H-imidazo[1,2,α]pyridine derivatives 5a-i and 6a-d are synthesized and characterized by IR, 1H NMR, 13C NMR and Mass spectral analysis. All the synthesized compounds were tested for there antibacterial and antifungal activity of which compound 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 6a, 6c and 6d exhibited good antimicrobial activity.

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Synthesis and Antitubercular Screening of 2-Chloro-N-(3-Cyano-4,5,6,7-Tetrahydro-1- Benzothiophen-2-Yl)Acetamide Clubbed

Synthesis and Antitubercular Screening of 2-Chloro-N-(3-Cyano-4,5,6,7-Tetrahydro-1- Benzothiophen-2-Yl)Acetamide Clubbed

Reactions of 2-chloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)acetamide with substituted 5-phenyl-1,3,4-oxadiazole-2 thiol gave N- (3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-aryl-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide were synthesized and assessed for their efficacy as antitubercular agents against tuberculosis H37Rv. The structural assignments of the new products were done on the basis of Infrared radiation (IR), Proton nuclear magnetic resonance (1H-NMR) and elemental analysis.

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55 views • 5 slides

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