'5 ss' diaporamas de présentation

In eukaryotes, large primary transcripts are processed to smaller, mature mRNAs.

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Predicting effect of SNPs and de novo mutations on splicing

Predicting effect of SNPs and de novo mutations on splicing. presented by Alexander Tchourbanov Biology Department New Mexico State University. Motivation. Recently, high throughput genotyping methods became available

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Exon skipping/inclusion

Exon skipping/inclusion. Alternative 3 ’ splice sites. Alternative 5 ’ splice sites. Mutual exon exclusion. Intron retention. 5 ’ ss. Branch Point. 3 ’ ss. exon1. exon2. GU. A. AG. exon1. exon2. GU. A. AG. U2. U1. UG. exon1. U1. U4/U6. U5. U2. A. exon2. AG. U4/U6.

387 views • 8 slides