International Journal of Neurological Disorders
Objective: Intracerebral Hemorrhage (ICH) induces Blood-Brain Barrier (BBB) dysfunction. The purpose of this study was to investigate whether Angong Niuhuang Pill (ANP) attenuates blood-brain barrier dysfunction by inhibiting lipopolysaccharide translocation in ICH mice. Methods: Male CD-1 mice were randomly divided into sham, ICH, and ANP-treated groups. The mice were subjected to intrastriatal injection of bacterial collagenase or PBS (Sham group). Then they were administered intragastrically with vehicle (for the sham and ICH group) or ANP (0.1, 0.2, or 0.4 g/kg) respectively.
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