'Alakaaaam alakaaaan alakaaaar alakaaaat' diaporamas de présentation

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Outline

Blast heuristics, Psi-Blast, and Sequence profiles Morten Nielsen Department of systems biology, DTU. Outline. B asic L ocal A lignment S earch T ool What are the Blast heuristics? How does Blast calculate E-values? What are the limits of Blast?

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Data driven method training

Cross validation , training and evaluation of data driven prediction methods Morten Nielsen Department of Systems Biology , DTU. Data driven method training. A prediction method contains a very large set of parameters

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Psi-Blast

Psi-Blast. Morten Nielsen, Department of systems biology, DTU. Objectives. Understand why BLAST often fails for low sequence similarity See the beauty of sequence profiles Position specific scoring matrices (PSSMs) Use BLAST to generate Sequence profiles

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