Alk1 - PowerPoint PPT Presentation

ALK1 a Novel Target for Angiogenesis Inhibition

Extracellular Domain of ALK1. ALK1. IgG1 Antibody. BMP9. BMP10. Type II. ALK1 Type I. Fc Domain of IgG1 Antibody. P. SMAD1/5/8. SMAD4. ACE-041 ALK1-Fc fusion protein. SRE. CD31. CONTROL. RAP-041.

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LacZ. wtALK1/HA. - TGF- b. - TGF- b. - TGF- b. +TGF- b. +TGF- b. +TGF- b. MEEC BRE-luc. 120. 100. 80. Luciferase activity (arbitrary unit s ). 60. 40. 20. 0. -. -. ALK1- RNAi. BAEC. A. MEEC BRE-luc. B. 45 min. 45 min. 90 min. 90 min. 180. TGF- b:. 3h. 2h. 2h. 3h.

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