Antitumor agent - PowerPoint PPT Presentation

Discovery and Synthesis of Alimta™, A New and Broadly Effective Antitumor Agent

Discovery and Synthesis of Alimta™, A New and Broadly Effective Antitumor Agent. Edward C. Taylor Department of Chemistry Princeton University Princeton, NJ 08544 etaylor@princeton.edu. The Pterin Ring of Folic Acid. Folic Acid, Aminopterin and Methotrexate.

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OVERVIEW OF AMINO ACID METABOLISM

OVERVIEW OF AMINO ACID METABOLISM. ENVIRONMENT ORGANISM. Bio- synthesis. Protein. Ingested protein. 2. 3. 1. a. AMINO ACIDS. b. c. Degradation (required). c. Purines Pyrimidines Porphyrins. Nitrogen. Carbon skeletons.

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Bergman Cyclization of Sterically Hindered Substrates and Observation of Phenyl-Shifted Products

M1 Colloquium in Division Frontier Materials Science in 2005. Bergman Cyclization of Sterically Hindered Substrates and Observation of Phenyl-Shifted Products. Kevin D. Lewis, and Adam J. Matzger* J. Am. Chem. Soc. 200 5 , 127, 9968. Tobe Laboratory Hiroyuki Kuge.

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