'Binding site' diaporamas de présentation

Basic Pharmacology

Basic Pharmacology. What is a drug? any chemical agent which effects any biological process. What is pharmacology ? the study of how drugs effect biological systems. Lange Katzung. Pharmacology

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Antigens

Antigens. March 4, 2003. Part I Introduction Chapter 1. Overview of the Immune System Chapter 2. Cells and Organs of the Immune System Part II Generation of B-cell and T-cell Responses Chapter 3. Antigens. ????: 1. Immunogenicity Versus Antigenicity

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DNA Replication: Clamp Loaders and Other AAA+ Machines Within the Replisome Scott Morrical

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Impact of functional information on understanding (genetic) variation ENCODE thread 12 + a bit more

Impact of functional information on understanding (genetic) variation ENCODE thread 12 + a bit more. ENCODE Journal Club David Vandenbergh Marta Byrska -Bishop Jan 8, 2013. Titles of the 3 papers. Personal and population genomics of human regulatory variation. Vernot B et al.

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Identification of Regulatory Binding Sites Using Minimum Spanning Trees

Identification of Regulatory Binding Sites Using Minimum Spanning Trees. Pacific Symposium on Biocomputing, pp. 327-338, 2003 Reporter: Chu-Ting Tseng Advisor: Prof. Chang-Biau Yang Date: Apr. 2, 2004. Outline. Introduction Minimum Spanning Tree (MST) Binding Site Identification by MST

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Patrick An Introduction to Medicinal Chemistry 3/e Chapter 6 PROTEINS AS DRUG TARGETS:

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 6 PROTEINS AS DRUG TARGETS: RECEPTOR STRUCTURE & SIGNAL TRANSDUCTION Part 2: Sections 6.3 - 6.6. Contents Part 2: Sections 6.3 - 6.6 3. G-protein-coupled receptors (7-TM receptors)

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Reaction Mechanism: Chicken Egg White Lysozyme

Reaction Mechanism: Chicken Egg White Lysozyme. Enzyme responsible for degrading bacterial cell walls Hydrolyzes the glycosidic linkage between NAM and NAG. Mechanism: Chicken Egg White Lysozyme. Substrate fits in groove in enzyme. Binding Site. Mechanism: Chicken Egg White Lysozyme.

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Case Study: The Binding Site. Working with the Recast/Revision of the IVD Directive - the Impact on a Medium-sized Diagn

Case Study: The Binding Site. Working with the Recast/Revision of the IVD Directive - the Impact on a Medium-sized Diagnostics Company. Dr Kirk Buller Head of Regulatory Affairs.

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Protein Synthesis

Protein Synthesis. Yes, it is still chapter 3!. It is the DNA in the nucleus that stores instructions for protein synthesis and this DNA is contained in chromosomes. Human body cells contain 23 pairs of chromosomes.

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Coding Theory and Protein Synthesis

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PROTEINS

PROTEINS. INTRODUCTION. Useful Proteins. There are thousands and thousands of different combinations of amino acids that can make up proteins and that would increase if each one had multiple shapes Proteins usually have only one useful conformation

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QUANTITATIVE ASPECTS OF DRUG ACTION

ilo s. By the end of this lecture you will be able to :. Determine quantitative aspects of drug receptor binding. Recognize different dose response curves. Distinguish the therapeutic utility of each of these curves. Classify different types of antagonism.

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In memory of Rich Green 1947 - 2001 An Outstanding Medicinal Chemist and Colleague

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GENE REGULATION

GENE REGULATION. Definition. The mechanisms that determine the types of cells in which a gene will be transcribed. When the mRNA will be exported to the cytoplasm. When and how often the mRNA will be translated, and the duration of time before the mRNA is degraded. Regulation categories.

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The Yeast Two-Hybrid System

The Yeast Two-Hybrid System. Anne C. Luebke. What is the yeast two-hybrid system used for?. Identifies novel protein-protein interactions Can identify protein cascades Identifies mutations that affect protein-protein binding

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E. Coli Fluorescing Red Using Cold Temperature Sensor

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Blood and Blood Spatter

Blood and Blood Spatter. Blood. 3 Types of Cells Red Blood Cells White Blood Cells Platelets All contained in plasma that contains proteins: Antibodies Hormones Clotting factors Nutrients (amino acids, minerals, etc.). Blood Cells. Red Blood Cells

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SiteEngine: Functional Sites Structural Search Engine

SiteEngine: Functional Sites Structural Search Engine. Shulman-Peleg A., Nussinov R. and Wolfson H. J. Recognition of Functional Sites in Proteins Structures, J. Mol. Biol. 339(3), 607 633. Complete protein Binding site. 3D transfor-mation. Similarity Score. Input. Output. SiteEngine.

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