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Tutorial 4 Substitution matrices and PSI-BLAST

Tutorial 4 Substitution matrices and PSI-BLAST. Agenda. Why study distant homologies? Substitution Matrices PAM - Point Accepted Mutations BLOSUM - Blocks Substitution Matrix PSI-BLAST Cool story of the day: Why should we care about cellular fusion in worms?. How proteins evolve.

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Tutorial 4 Substitution matrices and PSI-BLAST