'Brca2 mutations' diaporamas de présentation

Breast Cancer

Breast Cancer . Radiation Oncology II 4412. History . Recorded 5000 years ago Before 20 th century-William Halstead performed radical mastectomy Today we use multidisciplinary approach Radiation therapy Chemotherapy Hormone therapy Surgery. Epidemiology.

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The Angelina Jolie Example : Risk Reducing Surgery for Breast and Ovarian Cancer

The Angelina Jolie Example : Risk Reducing Surgery for Breast and Ovarian Cancer. SUMAYYA EBRAHIM GYNAECOLOGIST PARKLANE CLINIC JOHANNESBURG. MAY 2013. STATISTICS SOUTH AFRICA. NATIONAL CANCER REGISTRY Lifetime risk of ovarian cancer 1:82

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Genetic Epidemiology of Breast Cancer

Genetic Epidemiology of Breast Cancer. Susan Neuhausen, PhD Epidemiology Div., Dept. Medicine University of California Irvine Irvine, CA USA. Risk factors for disease. Inherited (exposure). Genotypes. Somatic (outcome).

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Multiplicative updates for the LASSO

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Cancer Research

Cancer Research. Sukhjeet bains Melissa Sylvester Wendy carpio Adriana monterroza. Central Nervous System Leukemia . Central Nervous system therapy is used to prevent possible relapses at the CNS site in ALL Advancements made in ALL are a result of this

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Genome+Environment = Traits, [diseases], (treatments)

Hair: Baldness [alopecia](minoxidil) Eyes: [Near/Far-sightedness](glasses) Iris color [ARMD] (glasses) Face: [Developmental syndromes, Wrinkles] (Botox) Brain: ADHD(Ritalin); Depression(Prozac); Headache(analgesics) Sleep & Circadian (caffeine, amphetamine, modafinil)

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Genome+Environment = Traits, [diseases], (treatments)

Hair: Baldness [alopecia](minoxidil) Eyes: [Near/Far-sightedness](glasses) Iris color [ARMD] (glasses) Face: [Developmental syndromes, Wrinkles] (Botox) Brain: ADHD(Ritalin); Depression(Prozac); Headache(analgesics) Sleep & Circadian (caffeine, amphetamine, modafinil)

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Breast Cancer is the most common cancer in women.

BRCA1 and BRCA2 are genes which normally help to prevent breast cancer by making proteins which inhibit abnormal cellular growth.

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The Inhibition of Polymerase in Tumors from BRCA Mutation Carriers

The Inhibition of Polymerase in Tumors from BRCA Mutation Carriers. Background. Inhibiting polyADP polymerase is key in the treatment of cancers that have DNA-repair defects. Methods.

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Table 1 Timing of clinical trials and FDA approval for selected targeted therapies

Table 1 Timing of clinical trials and FDA approval for selected targeted therapies. Maxwell, K. N. & Domchek, S. M. ( 2012) Cancer treatment according to BRCA1 and BRCA2 mutations Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2012.123.

169 views • 1 slides