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Figure 3 Diagnostic algorithm and therapeutic options for aHUS

Figure 3 Diagnostic algorithm and therapeutic options for aHUS

Figure 3 Diagnostic algorithm and therapeutic options for aHUS. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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nrneph.2012.214-pf2

nrneph.2012.214-pf2

Figure 2 Recovery of renal function is better with a shorter interval between onset of aHUS and initiation of eculizumab. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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nrneph.2012.214-pt1

nrneph.2012.214-pt1

Table 1 Evidence supporting the role of complement dysregulation and the benefit of C5 blockade in aHUS and C3G. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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nrneph.2012.214-pt2

nrneph.2012.214-pt2

Table 2 Clinical and genetic characteristics of 24 off-trial patients treated with eculizumab for overt aHUS. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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nrneph.2012.213 pf2

nrneph.2012.213 pf2

Figure 2 Activation of C3 convertase is involved in both complement-mediated and immune-complex-mediated MPGN. Bomback, A. S. & Appel, G. B. (2012) Pathogenesis of the C3 glomerulopathies and reclassification of MPGN Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.213.

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