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1000

1000

Figure 1. RYR1. Ca 2+ channel domain. 1000. 2000. 3000. 4000. 5000. COOH. NH 2. DHPR. IP 3 R. E4032. IP 3 -binding domain. Ca 2+ channel domain. 1000. 2000. NH 2. COOH. SII. SI. E2100. SII-. Type 1. Type 2. Type 3. Figure 2. A. 1000. 2000. IP 3 -binding domain.

By jerold
(134 views)

Short-term BP regulation (Neural mechanisms) Long-term BP regulation (Endocrine mechanisms)

Short-term BP regulation (Neural mechanisms) Long-term BP regulation (Endocrine mechanisms)

Blood pressure regulation. BP is directly proportional to the production of CO and PR (  CO or  PR =  BP). To maintain normal BP - CO and PR are controlled by 2 overlapping control mechanisms. Short-term BP regulation (Neural mechanisms)

By hakeem-holmes
(289 views)

The Control of Vascular Smooth Muscle Tone: Concepts Coming from Ca2 and cAMP Signalling

The Control of Vascular Smooth Muscle Tone: Concepts Coming from Ca2 and cAMP Signalling

\u041dH vascular smooth muscle tone must be well-controlled to assure a perfect regulation of blood pressure. In this arena, we have two important intracellular messengers: Ca2 and cAMP. Classically, the rise of intracellular Ca2 within vascular smooth muscle cells starts a well-organized symphony which reaches into muscle contraction. Nowadays, we know that Ca2 is an essential messenger that regulates vascular smooth muscle tone. \u041dus a dysregulation of Ca2 signalling may cause interferences on vascular tone. Besides Ca2 , there is another important messenger who regulates vascular tone: cAMP. But here, exerting an opposite H\u0648\u0674Hct compared to Ca2 : rising cAMP inside vascular smooth muscle cells relaxes smooth muscle, instead of contracting them like Ca2 does! Evidences indicate that cAMP may interfere on intracellular Ca2 stores like endoplasmic reticulum or may exert a direct H\u0648\u0674Hct on the contractile machinery, thus interfering with muscle contraction. Well, we have two messengers exerting opposite H\u0648\u0674Hcts One contracts, and the other one relaxes vascular smooth muscle.

By jessicamia1
(0 views)

Cardiac Electrophysiology

Cardiac Electrophysiology

Cardiac Electrophysiology. Qiang XIA ( 夏强 ), PhD Department of Physiology School of Medicine Tel: 88206417, 88208252 Email: xiaqiang@zju.edu.cn. The major types of cardiac muscle: Atrial muscle Ventricular muscle Specialized excitatory and conductive muscle. Contractile cells (收缩细胞).

By gentryb
(0 views)


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