Cd28 - PowerPoint PPT Presentation

PLC activation Ca++ flux NF-AT / NFkB nuclear localization protein tyrosine phosphorylation

}. IL-2 production proliferation. Ability to become an effector cell. T cell costimulation. What is meant by “costimulation”?. How does one define T cell activation?. PLC activation Ca++ flux NF-AT / NFkB nuclear localization protein tyrosine phosphorylation IL-2 production

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CTLA-4/CD28 Signaling Pathway

CD28 is the best characterized and most effective co-stimulatory molecule expressed by naive and primed T cells. CD28 is a 44-kDa glycoprotein that binds to B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells (APCs) CD28 might be associate, in its unphosphorylated state, with the serine/threonine protein phosphatase 2A (PP2A).

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