Chemical modifications - PowerPoint PPT Presentation

Epigenetics

Epigenetics. A nucleosome is the basic unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound in sequence around eight histone protein cores. This structure is often compared to thread wrapped around a spool.

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Delayed Neurotoxicity

Delayed Neurotoxicity. The cumulative risk at 5 years to develop overt dementia is 24-30% (1,2). For patients aged &gt; 60 year the risk of dementia at 7 years is 58% (2). Multivariate analysis shows that only radiotherapy is a significant factor related to neurotoxicity (1).

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