Circulation 2013 - PowerPoint PPT Presentation

Risk of major CV events by apoA-I quintiles per LDL-c category

Risk of major CV events by apoA-I quintiles per LDL-c category. apoA - I = 122 mg-dL. apoA - I = 122-137 mg-dL. apoA - I = 137-150 mg-dL. apoA - I = 150-168 mg-dL. apoA - I &gt; 168 mg-dL. Boekholdt et al . Circulation 2013.

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Desai et al., Circulation 2013

Lp(a) reduction after different dosing schemes of PCSK9 inhibition. AMG 145 Q2W. AMG 145 Q4W. 0. 70mg (n=75). 105mg (n=76). 140mg (n=73). 280mg (n=78). 350mg (n=79). 420mg (n=77). -10. -18.2. -18.0. LS Mean % change in Lp(a) from baseline to week 12. -20. -22.8.

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